A prospective evaluation of plasma phospholipid fatty acids and breast cancer risk in the EPIC study

Background Intakes of specific fatty acids have been postulated to impact breast cancer risk but epidemiological data based on dietary questionnaires remain conflicting. Materials and methods We assessed the association between plasma phospholipid fatty acids and breast cancer risk in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition study. Sixty…

Semiautomated determination of neonicotinoids and characteristic metabolite in urine samples using TurboFlow™ coupled to ultra high performance liquid chromatography coupled to Orbitrap analyzer

A semiautomated method based on ultra-high performance liquid chromatography (UHPLC) coupled to Orbitrap high resolution mass spectrometry has been developed for the determination of neonicotinoids (imidacloprid, acetamiprid, clothianidin, dinotefuran, nitenpyram, thiacloprid and thiamethoxam) and the metabolite acetamiprid-n-desmethyl in urine samples. Two automated methods were tested (solid-phase extraction “SPE” and turbulent flow chromatography “TurboFlow™”), obtaining the…

La activación de pacientes crónicos y su relación con el personal sanitario en Andalucía

Fundamento. Evaluar la (inter)relación entre la activación de pacientes crónicos y su relación con el personal sanitario en Andalucía. Material y métodos. Estudio cuantitativo realizado con 258  pacientes crónicos de la Escuela de Pacientes, que respondieron tras ser contactados por correo electrónico. De ellos, 142 completaron los cuestionarios. Se emplearon los cuestionarios Patient Activacion Measurement (PAM)…

Quality analysis of population-based information on cancer stage at diagnosis across Europe, with presentation of stage-specific cancer survival estimates: A EUROCARE-5 study

Background Cancer registries (CRs) are fundamental for estimating cancer burden, evaluating screening and monitoring health service performance. Stage at diagnosis—an essential information item collected by CRs—has been made available, for the first time, by CRs participating in EUROCARE-5. We analysed the quality of this information and estimated stage-specific survival across Europe for CRs with good data…

Determination of oleanolic acid in human plasma and its association with olive oil intake in healthy Spanish adults within the EPIC Spain cohort study

Scope Oleanolic acid (OA) is an important triterpenic compound found in olive oil, however little is known about its concentrations in human plasma. We aimed to determine plasma OA levels in a healthy Spanish population and compare them with estimates of dietary olive oil intake. Methods and results The final study sample included 141 individuals…

Barriers and enablers in the implementation of a program to reduce cesarean deliveries

Background Conducting audits, implementing best practices and giving feedback to the professionals have shown considerable promise in reducing rates of cesarean delivery and mother-child morbidity. The purpose of the study is two-fold: a) to identify the factors that facilitate change in current practices and thus reduce the use of obstetric interventions, and b) to better…

Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study

Background:The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective:To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design:Prospective cohort study. Setting:10 European countries. Participants:521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements:Hazard ratios (HRs) and 95% CIs estimated…