Adoption of the HPV vaccine: a case study of three emerging countries

Background: The human papillomavirus (HPV) vaccine has recently attracted considerable attention in emerging countries, due to its potential to reduce the impact of HPV-related diseases. This case study sheds new light about the variety of HTA arrangements, methods and processes involved in the adoption and use of HPV vaccines in a selected sample of central,…

Human adipose tissue levels of persistent organic pollutants and metabolic syndrome components: Combining a cross-sectional with a 10-year longitudinal study using a multi-pollutant approach

We aimed to assess the influence of long-term exposure to POPs on the risk of metabolic syndrome, combining a cross-sectional with a 10-year longitudinal follow-up design. Residues of eight POPs were quantified in adipose tissue samples from 387 participants recruited between 2003 and 2004 in Granada province (Spain). The outcome (“metabolically compromised”) was defined as…

HTA and decision-making processes in Central, Eastern and South Eastern Europe: Results from a survey

Objective To gain knowledge and insights on health technology assessment (HTA) and decision-making processes in Central, Eastern and South Eastern Europe (CESEE) countries. Methods A cross-sectional study was performed. Based on the literature, a questionnaire was developed in a multi-stage process. The questionnaire was arranged according to 5 broad domains: (i) introduction/country settings; (ii) use…

Demographic, lifestyle, and other factors in relation to antimüllerian hormone levels in mostly late premenopausal women

Objective To identify reproductive, lifestyle, hormonal, and other correlates of circulating antimüllerian hormone (AMH) concentrations in mostly late premenopausal women. Design Cross-sectional study. Setting Not applicable. Patient(s) A total of 671 premenopausal women not known to have cancer. Intervention(s) None. Main Outcome Measure(s) Concentrations of AMH were measured in a single laboratory using the picoAMH…

Correlates of circulating ovarian cancer early detection markers and their contribution to discrimination of early detection models: results from the EPIC cohort

Background Ovarian cancer early detection markers CA125, CA15.3, HE4, and CA72.4 vary between healthy women, limiting their utility for screening. Methods We evaluated cross-sectional relationships between lifestyle and reproductive factors and these markers among controls (n = 1910) from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Improvements in discrimination of…

Valoración de aspectos éticos y metodológicos en un estudio cualitativo con personas usuarias de Oncología Pediátrica

Fundamentos: En el marco de una investigación cualitativa con personas usuarias de Oncología Pediátrica y sus acompañantes, se diseñó y aplicó un instrumento de autoevaluación sobre aspectos éticos y metodológicos del estudio. Métodos: Investigación cualitativa con personas usuarias de Oncología Pediátrica y sus acompañantes, en cuatro Hospitales del Sistema Sanitario Público de Andalucía. Elaboración y…

Socio-economic factors linked with mental health during the recession: a multilevel analysis

Background Periods of financial crisis are associated with higher psychological stress among the population and greater use of mental health services. The objective is to analyse contextual factors associated with mental health among the Spanish population during the recession. Methodology Cross-sectional, descriptive study of two periods: before the recession (2006) and after therecession (2011-2012). The…