Unprocessed red meat and processed meat consumption and risk of stroke in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)

Background/Objectives: High intakes of unprocessed red or processed meat may increase the risk of stroke. We aimed to examine the association between unprocessed red meat, processed meat and total red meat consumption and risk of total stroke and ischaemic stroke. Subjects/Methods: Cox proportional hazards regression analyses were conducted based on the data for 41 020 men…

Survival of women with cancers of breast and genital organs in Europe 1999–2007: Results of the EUROCARE-5 study

Background Survival differences across Europe for patients with cancers of breast, uterus, cervix, ovary, vagina and vulva have been documented by previous EUROCARE studies. In the present EUROCARE-5 study we update survival estimates and investigate changes in country-specific and over time survival, discussing their relationship with incidence and mortality dynamics for cancers for which organised…

Prognoses and improvement for head and neck cancers diagnosed in Europe in early 2000s: The EUROCARE-5 population-based study

Background Head and neck (H&N) cancers are a heterogeneous group of malignancies, affecting various sites, with different prognoses. The aims of this study are to analyse survival for patients with H&N cancers in relation to tumour location, to assess the change in survival between European countries, and to investigate whether survival improved over time. Methods…

The Association between Glyceraldehyde-derived Advanced Glycation End-Products and Colorectal Cancer Risk

Background: A large proportion of colorectal cancers (CRC) are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds…

Desigualdades de género en la investigación en salud pública y epidemiología en España (2007-2014)

Objetivo Analizar las desigualdades de género en investigación en salud pública y epidemiología en España, en el periodo 2007-2014. Método Estudio descriptivo según sexo de posiciones de liderazgo del Centro de Investigación Biomédica en Red (CIBER), especialmente en el área temática de epidemiología y salud pública (CIBERESP) en 2014; de sociedades científicas de salud pública…

Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Background Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification…

Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study

Background Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors ¿ healthy weight, physical activity, non-smoking,…

Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk: A nested case-control study in non-smoking postmenopausal women from the EPIC cohort

Acrylamide, classified in 1994 by IARC as ‘probably carcinogenic to humans', was discovered in 2002 in some heat-treated, carbohydrate-rich foods. Four prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The purpose of this nested case-control study, based on the European Prospective Investigation into Cancer and…

Calibrated prevalence of infertility in 30- to 49-year-old women according to different approaches: a cross-sectional population-based study

STUDY QUESTION How does the estimated prevalence of infertility among 30- to 49-year-old women vary when using different approaches to its measurement? SUMMARY ANSWER The prevalence of women with difficulties in conceiving differed widely according to the measurement approach adopted. WHAT IS KNOWN ALREADY Establishing the true magnitude of infertility as a public health problem…

El estudio de las desigualdades sociales en la salud infantil y adolescente en España

Objetivo El objetivo del trabajo es recopilar y describir los estudios realizados en España sobre desigualdades sociales en salud infantil y adolescente, con especial énfasis en los determinantes sociales. Método En julio de 2012 se realizó una revisión sistemática en PubMed, MEDES, SCOPUS y COCHRANE. Se incluyeron estudios sobre desigualdades sociales en salud infantil y…