Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study

Background Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors ¿ healthy weight, physical activity, non-smoking,…

Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk: A nested case-control study in non-smoking postmenopausal women from the EPIC cohort

Acrylamide, classified in 1994 by IARC as ‘probably carcinogenic to humans’, was discovered in 2002 in some heat-treated, carbohydrate-rich foods. Four prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The purpose of this nested case-control study, based on the European Prospective Investigation into Cancer and…

Calibrated prevalence of infertility in 30- to 49-year-old women according to different approaches: a cross-sectional population-based study

STUDY QUESTION How does the estimated prevalence of infertility among 30- to 49-year-old women vary when using different approaches to its measurement? SUMMARY ANSWER The prevalence of women with difficulties in conceiving differed widely according to the measurement approach adopted. WHAT IS KNOWN ALREADY Establishing the true magnitude of infertility as a public health problem…

El estudio de las desigualdades sociales en la salud infantil y adolescente en España

Objetivo El objetivo del trabajo es recopilar y describir los estudios realizados en España sobre desigualdades sociales en salud infantil y adolescente, con especial énfasis en los determinantes sociales. Método En julio de 2012 se realizó una revisión sistemática en PubMed, MEDES, SCOPUS y COCHRANE. Se incluyeron estudios sobre desigualdades sociales en salud infantil y…

¿Es necesaria una estrategia integrada de biosocioética?

Objetivo El presente artículo reflexiona sobre la necesidad de apostar por la articulación de una estrategia de ética que incluya 2 de los pilares básicos que afectan al bienestar de las personas, la atención de los servicios sanitarios y de los servicios sociales. El objetivo es realizar un acercamiento a la percepción de profesionales de…

Plasma fetuin-A concentration, genetic variation in the AHSG gene and risk of colorectal cancer

Fetuin-A, also referred to as α2-Heremans-Schmid glycoprotein (AHSG), is a liver protein known to inhibit insulin actions. Hyperinsulinemia is a possible risk factor for colorectal cancer; however, the role of fetuin-A in the development of colorectal cancer is unclear. We investigated the association between circulating fetuin-A and colorectal cancer risk in a nested case–control study…

Trends in lung cancer incidence by histologic subtype in the south of Spain, 1985–2012: a population-based study

Purpose To analyze and interpret age- and sex-specific incidence trends of lung cancer in Granada over the period 1985–2012 and to further analyze these trends by histologic subtype. Methods Incidence data were obtained from the population-based cancer registry located in Granada (Southern Spain). All cases with newly diagnosed primary lung cancer over the period 1985–2012…

Polymorphisms of pesticide-metabolizing genes in children living in intensive farming communities

Polymorphisms in genes encoding xenobiotic-metabolizing enzymes (XME) are important parameters accounting for the wide inter-individual variability to environmental exposures. Paraoxonase-1 (PON1), butyrylcholinesterase (BChE) and Cytochrome-P450 constitute major classes of XME involved in the detoxification of pesticide chemicals, in particular organophosphates. This study explored the allelic frequency, linkage disequilibrium and haplotype analysis of ten common polymorphic…