Associations between dietary exposure to dioxins and polychlorinated biphenyls (PCBs) and Longitudinal changes in weight and waist circumference– an EPIC study

Background: Obesity is a growing global health concern. Some evidence suggests that exposure to polychlorinated biphenyls (PCBs) and dioxins, may play a role in weight gain, but human prospective data are limited and have shown inconsistent results. Therefore, this study investigate the association between dietary exposure to dioxins and PCBs and changes in weight and…

Intake of the Total, Classes, and Subclasses of (Poly)phenols and Breast Cancer Risk: A Prospective Analysis of the EPIC Study

Polyphenols represent the largest and most diverse class of dietary antioxidants. Epidemiological evidence linking specific (poly)phenol classes, such as flavonoids and lignans, to breast cancer (BC) risk remains limited and largely inconclusive in prospective studies. The aim of this study is to examine the association between the intake of total (poly)phenols—and its classes and subclasses—and…

Evaluación Impacto de la Salud

Guía Técnica para la Evaluación del Impacto en la Salud en España Aplicación en el contexto de la Sanidad Ambiental COORDINACIÓN Ministerio de Sanidad, Subdirección General de Sanidad Ambiental y Salud Laboral: Margarita Palau Miguel, Marian Mendoza García, Francisco Vargas Marcos AUTORES Ministerio de Sanidad, Subdirección General de Sanidad Ambiental y Salud Laboral: Rosina Magdalena…

Antropología feminista

ANTROPOLOGÍA FEMINISTA abrazar saberes, compartir horizontes Carmen Gregorio Gil (Editora) , Herminia Gonzálvez Torralbo (Editora) , Lola Martínez-Pozo (Editora) Este libro constituye una lectura imprescindible para quienes deseen conocer con perspectiva feminista algunas de las problemáticas que aborda la Antropología social. La lectura nos acerca a asuntos de largo recorrido en la disciplina antropológica como las desigualdades de género, parentesco,…

Premenopausal and postmenopausal obesity and endometrial cancer risk: circulating biomarkers of inflammation, insulin resistance, and sex hormones as mediators

Background Obesity may increase endometrial cancer risk through pathways involving chronic inflammation, insulin resistance, and altered sex hormone levels. Methods Within the European Prospective Investigation into Cancer and Nutrition cohort, we investigated these mediating pathways using prediagnostic circulating biomarkers measured in 337 matched case-control pairs with postmenopausal measurements and 196 pairs with premenopausal measurements. We…

Assessing the role of ultra-processed foods in colorectal cancer incidence: insights from the EPIC cohort

Background Studies have reported associations between ultra-processed food (UPF) consumption and colorectal cancer (CRC) incidence, yet the magnitude of these associations remains unclear. This study estimated the cohort-associated fraction (CAF), adapted from the population-attributable fraction metric, between UPF consumption and CRC incidence and explored the potential benefits of substituting UPFs with unprocessed or minimally processed…

A data-driven framework for predicting PEG-defined MacroB12 in hypercobalaminemia

MacroB12 interference presents a significant challenge in the diagnosis of Vitamin B12 status, potentially masking true deficiency. To establish robust predictors and quantify the utility of pre-polyethene glycol (PEG) B12 levels, we conducted a retrospective analysis of 875 individuals with hypercobalaminemia (>1000 pg/mL), using multiple imputation to handle missing data. Multivariable regression modelling revealed that PEG-defined…

Mapping the landscape of managed entry agreements: a systematic review of global frameworks, system-level components, and implementation challenges

Background: Managed Entry Agreements (MEAs) are pivotal for enabling access to innovative pharmaceuticals while mitigating financial risk and addressing evidence uncertainty. Despite conceptual acceptance, the essential requirements for their design and implementation are poorly documented, posing a challenge for evolving health systems. This study aimed to systematically review and map global evidence published in the…

Linking Nutri-Score dietary profiles to metabolic biomarkers in a cross-sectional study within the multinational EPIC cohort

The front-of-pack label Nutri-Score has been implemented in several European countries since 2017 to guide consumers towards foods of higher nutritional value. A few studies reported associations between Nutri-Score dietary profiles reflecting a lower nutritional quality, however not using the 2023-updated version of the algorithm, and profiles of biomarkers consistent with increased metabolic risk. Our…