Comorbidities, age and period of diagnosis influence treatment and outcomes in early breast cancer

Survival for breast cancer (BC) is lower in eastern than northern/central Europe, and in older than younger women. We analysed how comorbidities at diagnosis affected whether selected standard treatments (STs) were given, across Europe and over time, also assessing consequences for survival/relapse. We analysed 7,581 stage I/IIA cases diagnosed in 9 European countries in 2009−13,…

Comorbidities, timing of treatments, and chemotherapy use influence outcomes in stage III colon cancer: A population-based European study

Introduction For stage III colon cancer (CC), surgery followed by chemotherapy is the main curative approach, although optimum times between diagnosis and surgery, and surgery and chemotherapy, have not been established. Materials and methods We analysed a population-based sample of 1912 stage III CC cases diagnosed in eight European countries in 2009–2013 aiming to estimate:…

Comparabilidad de las ediciones 2006/7 y 2011/12 de la Encuesta Nacional de Salud de España

Fundamentos: La Encuesta Nacional de Salud de España (ENSE) es una de las fuentes principales sobre determinantes sociales de la salud. Los objetivos de este trabajo fueron describir el procedimiento de fusión de las ediciones 2006/07 y 2011/12 de la ENSE, y proporcionar acceso libre a las bases de datos y directorio de variables. Métodos:…

Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort

The etiology of small intestinal cancer (SIC) is largely unknown, and there are very few epidemiological studies published to date. No studies have investigated abdominal adiposity in relation to SIC. Methods We investigated overall obesity and abdominal adiposity in relation to SIC in the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective…

Comparison of prognostic models to predict the occurrence of colorectal cancer in asymptomatic individuals: a systematic literature review and external validation in the EPIC and UK Biobank prospective cohort studies

Objective To systematically identify and validate published colorectal cancer risk prediction models that do not require invasive testing in two large population-based prospective cohorts. Design Models were identified through an update of a published systematic review and validated in the European Prospective Investigation into Cancer and Nutrition (EPIC) and the UK Biobank. The performance of…

Competition in the off-patent medicine market in Spain: The national reference pricing system versus the regional system of tendering for outpatient prescription medicines in Andalusia

Spain has a reference price system (RPS) for off-patent medicines since 1997. In addition, from 2012, Andalusia is running a series of tenders for procuring off-patent medicines dispensed by community pharmacies, for those medicines included in the system of homogenous clusters within the national reference price system. Such tenders offer additional savings to the regional…

Compliance with Supportive Periodontal/Peri‐Implant Therapy: A Systematic Review

Aim The present systematic review aimed at assessing the degree of compliance with supportive periodontal/peri‐implant therapy as well as identifying patient‐related factors that could potentially play a role on patient compliance. Methods Electronic and manual literature searches were carried out to assess patient compliance during maintenance. Main outcomes were compliance definition, degree of compliance and…

Comprehension and Recall of Information about Factors Associated to Peri‐Implantitis: A Randomized Controlled Trial

Aim : To evaluate the effect of different communication strategies on comprehension and recall of information about factors associated to peri‐implantitis. Material and methods : A prospective, randomized controlled trial was conducted in consecutive patients diagnosed with peri‐implantitis. The sample was divided into three groups according to the communication strategy used: Test group1 – Written communication…

Concentrations of bisphenol-A in adults from the general population: A systematic review and meta-analysis

Background Human bisphenol-A (BPA) exposure has been linked to adverse health effects even at low doses, which may be of potential public health concern. Objective To summarize BPA concentrations in general human population and their variability according to sex, geographic area, and analytical method. Methods Systematic review and meta-analysis of studies reporting BPA concentrations in…