Reassessing the association between age at menarche and cardiovascular disease: observational and Mendelian randomization analyses

Aims Observational studies have shown a U-shaped association between age at menarche (AAM) and cardiovascular disease (CVD). We assessed non-linearity of the observational association and the potential causal relationship between AAM and CVD using data from the European Prospective Investigation into Cancer and Nutrition—Cardiovascular Disease (EPIC-CVD) study and the UK Biobank. Methods and results We…

Sexual Dysfunction in Women With Eating Disorders: Systematic Review and Meta-Analysis

Background Eating disorders (EDs) are common mental health conditions that impact people globally. Sexual health problems are also widely researched across various contexts. This paper explores the connection between these two areas by conducting a meta-analysis to assess sexual dysfunction (SD) in women with EDs compared to healthy individuals. Methods Multiple electronic databases were searched.…

Gender Differences in Clinical Practice Regarding Coronary Heart Disease: A Systematic Review

Background/Objectives: A systematic review was performed with the aim of analysing potential sex differences in the overall treatment of coronary heart disease (CHD). Methods: Studies published between January 2011 and November 2023 that conducted a sex-based analysis of the provision of any type of therapeutic measure to treat CHD were included. A search was performed…

Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations

Gut barrier dysfunction and related inflammation are known to be associated with the development and progression of colorectal cancer (CRC). We investigated associations of 292 single-nucleotide polymorphisms (SNPs) from 27 genes related to endotoxins/lipopolysaccharide (LPS) sensing and tolerance, mucin synthesis, inflammation, and Crohn’s disease with colon and rectal cancer risks. Incident CRC cases (N = 1374; colon = 871,…

Informe Salud y Género 2025

Informe Salud y Género en Andalucía Edita: Consejería de Salud y Consumo Responsable de edición: Dirección General de Salud Pública y Ordenación Farmacéutica Elabora: Escuela Andaluza de Salud Pública. Junta de Andalucía | Febrero, 2025 Coordinación General: Teresa Campos García Servicio de Coordinación de la Dirección General de Salud Pública y Ordenación Farmacéutica. Consejería de…

Comprehensive analysis of West Nile Virus transmission: Environmental, ecological, and individual factors. An umbrella review

Background West Nile Virus (WNV) exemplifies the complexities of managing vector-borne diseases, expanding globally due to human activities and ecological changes. Originating from Africa and transmitted by Culex mosquitoes, WNV is now reported across multiple continents. The aim of this study was to identify the environmental, ecological, and individual factors influencing WNV transmission. Methods An…

Higher intakes of dietary dicarbonyl compounds are associated with lower risk of cardiovascular disease

Aims Dicarbonyl compounds such as methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG) are present in numerous foods. They are pro-inflammatory and pro-oxidative, but their potential role in cardiovascular disease (CVD) development has been scarcely studied. We explored associations between dietary dicarbonyls with fatal and non-fatal CVD. Methods and results We conducted a case-cohort analysis based…

Adherence to the Mediterranean Diet and Obesity-Linked Cancer Risk in EPIC

Importance  Adherence to the Mediterranean Diet (MedDiet) has been associated with a lower incidence of cancer and reduced weight gain. These associations suggest a potential role for the MedDiet in lowering the risk of obesity-related cancers (ORCs). Obesity is a known risk factor for various cancers and shows an inverse association with MedDiet adherence. Objective …

A longitudinal Analysis of the Association between Socioeconomic Position and Multimorbidity in the European Prospective Investigation into Cancer and Nutrition Study

The association between socioeconomic position (SEP) and non-communicable diseases (NCDs) is well established, but its role in driving multimorbidity remains unclear. Multimorbidity, defined as the co-occurrence of more the one chronic condition, is linked to higher mortality and reduced quality of life. This study investigates the association between SEP and multimorbidity using data from the…

Association of circulating fatty acids with cardiovascular disease risk: analysis of individual-level data in three large prospective cohorts and updated meta-analysis

Aims Associations of saturated and unsaturated fatty acids (FAs) with cardiovascular disease (CVD) remain controversial. We therefore aimed to investigate the prospective associations of objectively measured FAs with CVD, including incident coronary heart disease (CHD) and stroke, as well as CVD mortality. Methods and results Circulating FA concentrations expressed as the percentage of total FAs…