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Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. Methods: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and…

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Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses

Artículos Científicos, Investigación, Mujeres EASP

Background: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. Methods: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and…

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Micronutrients, Vitamin D, and Inflammatory Biomarkers in COVID-19: A Systematic Review and Meta-analysis of Causal Inference Studies

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Context Experimental and observational studies suggest that circulating micronutrients, including vitamin D (VD), may increase COVID-19 risk and its associated outcomes. Mendelian randomization (MR) studies provide valuable insight into the causal relationship between an exposure and disease outcomes. Objectives The aim was to conduct a systematic review and meta-analysis of causal inference studies that apply MR…

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Microcephaly Epidemic in Brazil: An Earlier Chapter

Artículos Científicos

Objective: Identify risk factors for microcephaly and evaluate historical trends of microcephaly and arboviruses to recognize patterns and anomalies that indicate the beginning of the microcephaly epidemic associated with Zika infection. Methods: The head circumferences of 62,298 newborns was analyzed to identify cases of microcephaly between 2014 and 2017. We compared the groups of newborns…

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Mi chico no quiere usar condón. Estrategias innovadoras para la prevención de la transmisión sexual del VIH/sida

Publicaciones EASP

Llevamos bastantes años investigando las conductas sexuales de los jóvenes, y sabemos ya qué hacen, cómo lo hacen y cuántos y cuántas lo hacen. Llevamos también algunos años investigando las razones por las que llevan a cabo prácticas sexuales de riesgo respecto a la transmisión del VIH/sida, y sabemos ya por qué hacen lo que…

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Metodología de investigación y escritura científica en clínica

Publicaciones EASP

La aparición de la Edición 1998 de «Metodología de investigación y escritura científica en clínica» plantea dos preguntas importantes: Pregunta nº 1: «¿Qué material nuevo trae esta edición?» En primer lugar, la sección IV.B.5. «Las etapas del proceso de investigación en salud» se ha reescrito totalmente reagrupando los 18 pasos que componen las etapas conceptual…

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Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism and Infant’s Anthropometry at Birth

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Identification of causal factors that influence fetal growth and anthropometry at birth is of great importance as they provide information about increased risk of disease throughout life. The association between maternal genetic polymorphism MTHFR(677)C>T and anthropometry at birth has been widely studied because of its key role in the one-carbon cycle. MTHFR(677) CT and TT…

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Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort

Artículos Científicos

Background The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases. Objectives First, to summarize the main design features of a prospective case-control study –nested within the European Prospective Investigation into Cancer and Nutrition…

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Methodological issues in a prospective study on plasma concentrations of persistent organic pollutants and pancreatic cancer risk within the EPIC cohort

Artículos Científicos

Background The use of biomarkers of environmental exposure to explore new risk factors for pancreatic cancer presents clinical, logistic, and methodological challenges that are also relevant in research on other complex diseases. Objectives First, to summarize the main design features of a prospective case-control study –nested within the European Prospective Investigation into Cancer and Nutrition…

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Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Artículos Científicos

Background Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification…