Human Papillomavirus Antibodies and Future Risk of Anogenital Cancer: A Nested Case-Control Study in the European Prospective Investigation Into Cancer and Nutrition Study

Purpose: Human papillomavirus (HPV) type 16 (HPV16) causes cancer at several anatomic sites. In the European Prospective Investigation Into Cancer and Nutrition study, HPV16 E6 seropositivity was present more than 10 years before oropharyngeal cancer diagnosis and was nearly absent in controls. The current study sought to evaluate the extent to which HPV16 E6 antibodies…

Identificación de barreras y facilitadores para la (des)prescripción de benzodiacepinas: un estudio cualitativo con pacientes y profesionales sanitarios

Fundamento. La tendencia en la prescripción de benzodiacepinas ha crecido en la última década. España está entre los países donde este tipo de fármacos es el más prescrito por profesionales en Atención Primaria. El propósito de este estudio es identificar factores que podrían estar actuando como barreras y facilitadores en la (des)prescripción de benzodiacepinas desde…

Identificación de indicadores de buenas prácticas en gestión clínica y sanitaria

Objetivo Identificar buenas prácticas para desarrollar e implementar indicadores de resultados en salud para la gestión clínica y sanitaria. Metodología Revisión exploratoria de la literatura (scoping review), con las fases: 1) búsqueda e identificación de bibliografía; 2) selección de documentos relevantes. Se incluyeron estudios que discutían buenas prácticas para la utilización de indicadores en salud…

Identificación de indicadores de resultado en salud en atención primaria. Una revisión de revisiones sistemáticas

Introducción Las medidas de resultados están siendo ampliamente utilizadas por los servicios sanitarios para evaluar la calidad de la atención sanitaria. Disponer de una batería de indicadores de resultados de alta validez y factibilidad y que además sean de utilidad resulta de gran importancia. Así, el objetivo de este trabajo es realizar una revisión de…

Identification and prioritisation of risks in a hospital pharmacy using healthcare failure mode and effect analysis

Objectives The goals of this project included identifying the processes and subprocesses performed in hospital pharmacies, identifying potential adverse events, detecting failure modes and the causes of errors, prioritising the risks identified and designing a map of risks for hospital pharmacies. Methods A task force composed of hospital pharmacy staff was committed to update the…

Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer

Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10−8) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative…

Impact of COVID-19 on the Health of the General and More Vulnerable Population and Its Determinants: Health Care and Social Survey–ESSOC, Study Protocol

This manuscript describes the rationale and protocol of a real-world data (RWD) study entitled Health Care and Social Survey (ESSOC, Encuesta Sanitaria y Social). The study’s objective is to determine the magnitude, characteristics, and evolution of the COVID-19 impact on overall health as well as the socioeconomic, psychosocial, behavioural, occupational, environmental, and clinical determinants of…

Impact of cumulative body mass index and cardiometabolic diseases on survival among patients with colorectal and breast cancer: a multi-centre cohort study

Background Body mass index (BMI) and cardiometabolic comorbidities such as cardiovascular disease and type 2 diabetes have been studied as negative prognostic factors in cancer survival, but possible dependencies in the mechanisms underlying these associations remain largely unexplored. We analysed these associations in colorectal and breast cancer patients. Methods Based on repeated BMI assessments of…

Impact of lockdown on COVID-19 incidence and mortality in China: an interrupted time series study

Objective: to evaluate the effectiveness of strict social distancing measures applied in China in reducing the incidence and mortality from COVID-19 in two Chinese provinces. Methods: We assessed incidence and mortality rates in Hubei and Guangdong before and after the lockdown period in cities in Hubei. An interrupted time series study was conducted to evaluate the effectiveness of…