Prospective analysis of circulating metabolites and breast cancer in EPIC

Background Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk. Methods A nested case-control study was established within the European Prospective Investigation into Cancer cohort, which included 1624 first primary incident invasive…

Prospective analysis of circulating metabolites and endometrial cancer risk

Background Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective Investigation into Cancer…

Prospective association of liver function biomarkers with development of hepatobiliary cancers

Introduction Serum liver biomarkers (gamma-glutamyl transferase, GGT; alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; total bilirubin) are used as indicators of liver disease, but there is currently little data on their prospective association with risk of hepatobiliary cancers. Methods A nested-case control study was conducted within the prospective EPIC cohort (>520,000 participants, 10…

Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer

The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre-diagnostically. We assessed the association of antibody responses to SGG proteins in pre-diagnostic serum samples with CRC…

Protocolo del Estudio Poblacional Multinivel de las Desigualdades Socioeconómicas en la Distribución Geográfica de la Incidencia, la Mortalidad y la Supervivencia Neta del Cáncer en España: Estudio DESOCANES

La incidencia y la mortalidad brindan información sobre la carga de la morbilidad del cáncer y los años potenciales de vida perdidos debido al cáncer. Se ha desarrollado el Índice de Privación (IP) como una medida estandarizada para medir la privación socioeconómica en España a nivel de sección censal. Además, se puede combinar la información…

PSS15 – Economic Evaluation for The Treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI) From The NHS Perspective: A Spending Predictor Model for Italy, Romania and Spain

Objectives Dalbavancin is a new innovative long-acting antimicrobial treatment of Acute Bacterial Skin and Skin Structure Infections (ABSSSI) that allows clinicians to endorse an early discharge (ED) approach. Aim of this study was to develop a spending predictor model for evaluating the direct costs associated with the management of ABSSSI from a National Payer perspective…

Psychological and cognitive factors related to prehospital delay in acute coronary syndrome: A systematic review

Background In acute coronary syndrome the time elapsed between the start of symptoms and the moment the patient receives treatment is an important determinant of survival and subsequent recovery. However, many patients do not receive treatment as quickly as recommended, mostly due to substantial prehospital delays such as waiting to seek medical attention after symptoms…

Psychosocial markers of pre‐hospital decision delay and psychological distress in acute coronary syndrome patients

Objectives Both pre‐hospital decision delay – the time patients wait before seeking medical attention after symptoms have started – and high psychological distress after the cardiac episode predict poor prognosis of patients with acute coronary syndromes (ACS). We aimed to identify psychosocial markers of these prognostic factors. Design A cross‐sectional study of 102 consecutive, clinically…

Public health policies for the common interest: rethinking EU states’ incentives strategies when a pandemic reshuffles all interests

The paper “Should governments buy the drug patents?” published 13 years ago in this same journal [1] reflected on aspects that have become relevant again, both for good and bad reasons. The last 60 years have seen huge advances in many of the scientific, technological, and managerial factors that raises the efficiency of commercial medicines research…