Prediagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma

Bile acids (BAs) play different roles in cancer development. Some are carcinogenic and BA signaling is also involved in various metabolic, inflammatory and immune-related processes. The liver is the primary site of BA synthesis. Liver dysfunction and microbiome compositional changes, such as during hepatocellular carcinoma (HCC) development, may modulate BA metabolism increasing concentration of carcinogenic…

Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Background: Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract. Objective: We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and…

Predicting circulating CA125 levels among healthy premenopausal women

Background: CA125 is the most promising ovarian cancer screening biomarker to date. Multiple studies reported CA125 levels vary by personal characteristics, which could inform personalized CA125 thresholds. However, this has not been well described in premenopausal women. Methods: We evaluated predictors of CA125 levels among 815 premenopausal women from the New England Case Control Study…

Predictive Model and Mortality Risk Score during Admission for Ischaemic Stroke with Conservative Treatment

Background: Stroke is the second cause of mortality worldwide and the first in women. The aim of this study is to develop a predictive model to estimate the risk of mortality in the admission of patients who have not received reperfusion treatment. Methods: A retrospective cohort study was conducted of a clinical–administrative database, reflecting all…

Prenatal perfluoroalkyl substance exposure and neuropsychological development throughout childhood: The INMA Project

Background Perfluoroalkyl substances (PFASs) have been related to neurodevelopmental toxicity in animals. However, human studies are inconclusive. Objectives To evaluate the association between prenatal PFAS exposure and neuropsychological development during childhood. Methods 1240 mother–child pairs from the Spanish INMA Project were analyzed. Perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), and perfluorononanoic acid (PFNA)…

Preoperative use of statins does not improve outcomes and development of acute renal failure after cardiac surgery. A propensity score analysis of ARIAM-Andalucía database

Statin use prior to cardiac surgery has been reported to improve outcomes in the postoperative period because of other effects apart from decreasing lipid levels. Objective of the study was to analyse mortality and acute renal failure (ARF) during the cardiac surgery postoperative period in patients treated with or without statins. METHODS: This prospective cohort…

Prevalence and correlates of major depression in Granada, Spain: Results from the GranadΣp study

Background: Major depression is one of the world’s leading causes of disability. Up-to-date information about the epidemiology of this disorder is key to health care planning. Aim: The aim of our study is to report prevalence and correlates of current major depressive disorder (MDD) in the province of Granada, Southern Spain. Methods: The GranadΣp is…

Prevalencia de la violencia de parejas en España: estudio transversal a través de cuestionario en la atención primaria

Objetivos 1) Analizar la prevalencia de Violencia de Pareja por tipos. 2) Examinar la relación entre las características sociodemográficas y la Violencia de Pareja. Diseño Estudio transversal a través de cuestionario autoadministrado. Emplazamiento Centros de Atención Primaria en España. Participantes 10.322 mujeres (de 18 a 70 años) asistentes a Centros de Atención Primaria. Mediciones principales…