Programa de Intervención Educativa: Aprende a Crecer con Seguridad
Accidentes Infantiles. Tipología, causas y recomendaciones para la prevención Uds. didácticas y Fichas Secundaria Uds. didácticas Primaria Fichas Primaria
Projecting Pharmaceutical Expenditure in EU5 to 2021: Adjusting for the Impact of Discounts and Rebates
Background Within (European) healthcare systems, the predominant goal for pharmaceutical expenditure is cost containment. This is due to a general belief among healthcare policy makers that pharmaceutical expenditure—driven by high prices—will be unsustainable unless further reforms are enacted. Objective The aim of this paper is to provide more realistic expectations of pharmaceutical expenditure for all…
Prolactin Determinants in Healthy Women: A Large Cross-Sectional Study within the EPIC Cohort
Background: Experimental and epidemiologic data suggest that higher circulating prolactin is associated with breast cancer risk; however, how various risk factors for breast cancer influence prolactin levels in healthy women is not clear. Methods: We analyzed cross-sectional associations between several suggested reproductive and lifestyle risk factors for breast cancer and circulating prolactin among pre- and…
Promoción de la salud basada en activos: ¿cómo trabajar con esta perspectiva en intervenciones locales?
La incorporación del modelo de activos para la salud en las intervenciones de salud comunitaria/promoción de la salud puede reforzar aspectos relacionados con la equidad, la orientación a los determinantes sociales, la intersectorialidad y la participación en dichas intervenciones.
Promoción de salud: un enfoque en salud pública
Serie Documentos Técnicos. Seminario 1994
Prospective analysis of circulating metabolites and breast cancer in EPIC
Background Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk. Methods A nested case-control study was established within the European Prospective Investigation into Cancer cohort, which included 1624 first primary incident invasive…
Prospective analysis of circulating metabolites and endometrial cancer risk
Background Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective Investigation into Cancer…
Prospective association of liver function biomarkers with development of hepatobiliary cancers
Introduction Serum liver biomarkers (gamma-glutamyl transferase, GGT; alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; total bilirubin) are used as indicators of liver disease, but there is currently little data on their prospective association with risk of hepatobiliary cancers. Methods A nested-case control study was conducted within the prospective EPIC cohort (>520,000 participants, 10…
Prospective evaluation of 92 serum protein biomarkers for early detection of ovarian cancer
Background CA125 is the best available yet insufficiently sensitive biomarker for early detection of ovarian cancer. There is a need to identify novel biomarkers, which individually or in combination with CA125 can achieve adequate sensitivity and specificity for the detection of earlier-stage ovarian cancer. Methods In the European Prospective Investigation into Cancer and Nutrition (EPIC)…
Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer
The gut microbiome is increasingly implicated in colorectal cancer (CRC) development. A subgroup of patients diagnosed with CRC show high antibody responses to Streptococcus gallolyticus subspecies gallolyticus (SGG). However, it is unclear whether the association is also present pre-diagnostically. We assessed the association of antibody responses to SGG proteins in pre-diagnostic serum samples with CRC…