The economic burden of anxiety and depression on the working age population with diabetes in Spain

Diabetes mellitus (DM) is a complex, chronic, multifactorial, and costly health problem representing 8% of total public health expenditures in Spain. The objective of this study was to analyse the prevalence and costs of Anxiety (AX) and Depression (DP) in the Spanish working population with DM. Data were obtained from the National Health Survey of…

The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries

Aim To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. Methods and results We analysed data on 418 329 men and women from nine European countries, with an average of 12.7 years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over…

The Association between Glyceraldehyde-derived Advanced Glycation End-Products and Colorectal Cancer Risk

Background: A large proportion of colorectal cancers (CRC) are thought to be associated with unhealthy dietary and lifestyle exposures, particularly energy excess, obesity, hyperinsulinemia and hyperglycemia. It has been suggested that these processes stimulate the production of toxic reactive carbonyls from sugars such as glyceraldehyde. Glyceraldehyde contributes to the production of a group of compounds…

The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance;…

Tendencia de la obesidad infantil y el bajo peso por año de nacimiento y edad en España, 1983-2011

Introducción y objetivos Las prevalencias de obesidad infantil y sobrepeso están en aumento en todo el mundo y representan un importante problema de salud pública, especialmente en los perfiles de riesgo cardiovascular en la edad adulta si la obesidad no se revierte. La identificación precisa de las tendencias y los subgrupos en riesgo es crucial…

Tecnologías de la información en la gestión del conocimiento en el ámbito hospitalario

Los sistemas operacionales o transaccionales han permitido hacer más eficientes las organizaciones, capacitándolas para procesar un enorme volumen de transacciones de manera óptima, mejorando así la logística, el tratamiento de la información y prestando un mejor servicio al ciudadano. Esta publicación de 2004 venía a llenar un vacío en lengua española sobre estos temas, estableciendo…

Targeted maximum likelihood estimation for a binary treatment: A tutorial

When estimating the average effect of a binary treatment (or exposure) on an outcome, methods that incorporate propensity scores, the G‐formula, or targeted maximum likelihood estimation (TMLE) are preferred over naïve regression approaches, which are biased under misspecification of a parametric outcome model. In contrast propensity score methods require the correct specification of an exposure…

Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study

Background The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not differentiated between high-grade or advanced stage tumours, but rather have assessed risk with a combined category of aggressive disease. We investigated the association of height and adiposity with incidence of…

Systematic reviews on neurodevelopmental and neurodegenerative disorders linked to pesticide exposure: Methodological features and impact on risk assessment

Background Epidemiological data are not currently used in the risk assessment of chemical substances in a systematic and consistent manner. However, systematic reviews (SRs) could be useful for risk assessment as they appraise and synthesize the best epidemiological knowledge available. Objectives To conduct a comprehensive literature search of SRs pertaining to pesticide exposure and various…