Receptor activator of nuclear factor kB ligand, osteoprotegerin, and risk of death following a breast cancer diagnosis: results from the EPIC cohort

Background Receptor activator of nuclear factor kappa-B (RANK)-signaling is involved in tumor growth and spread in experimental models. Binding of RANK ligand (RANKL) to RANK activates signaling, which is inhibited by osteoprotegerin (OPG). We have previously shown that circulating soluble RANKL (sRANKL) and OPG are associated with breast cancer risk. Here we extend these findings…

Recesión bibliográfica: Health technology assessment and health policy today: a multifaceted view of their unstable crossroads

Recensión bibliográfica Del Llano Señarís JE, Campillo-Artero C, directores. Health technology assessment and health policy today: a multifaceted view of their unstable crossroads. En: Ortún V, director. Colección «Economía de la salud y gestión sanitaria». Madrid: Springer Healthcare Communications Ibérica; 2014. 156 p. ISBN: 978-84-940118-5-6

Recognizing a Heart Attack: Patients’ Knowledge of Cardiovascular Risk Factors and Its Relation to Prehospital Decision Delay in Acute Coronary Syndrome

In acute coronary syndromes (ACSs), longer decision delay – the time patients wait before seeking medical attention after symptoms have started – increases the risk of complications and death. However, many patients wait much longer than recommended and research is needed investigating how patient decision delay can be reduced. In a cross-sectional study of 120…

Red blood cell fatty acids and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).

Background: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer (CRC) risk. However, data from large-scale epidemiological studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce. Methods: To investigate the association between red blood cell (RBC) membrane FAs and…

Redes personales de apoyo y cuidado informal: ¿diferencias por sexo y territorio? (estudio CUIDAR-SE II)

Objetivo Comparar la composición y la funcionalidad de apoyo social de redes personales de personas cuidadoras de Granada y Gipuzkoa en función del sexo y la provincia. Método Estudio transversal con metodología de análisis de redes personales. Se seleccionó una muestra de 66 personas cuidadoras segmentada por sexo en cada provincia. Se recogieron variables de…

Reflexiones sobre cómo evaluar y mejorar la respuesta a la pandemia de COVID-19

La pandemia de COVID-19ha afectado de manera particularmente intensa a España, pese a su nivel de desarrollo y la elogiada solidez de su Sistema Nacional de Salud. Para comprender qué ha pasado e identificar cómo mejorar la respuesta creemos imprescindible una evaluación independiente multidisciplinaria de la esfera sanitaria, política y socioeconómica. En este trabajo proponemos…

Regional Versus Centralized Hta: Implications for the Assessment of Cancer Drugs

Different jurisdictions organize their health technology assessment (HTA) capacity in different ways. In theory, a centralized approach offers the potential to pool the scarce resources devoted to HTA and national recommendations can be issued to encourage a uniform development of services across the whole country. On the other hand, a regional approach could help in…

Relationship between exposure to mixtures of persistent, bioaccumulative, and toxic chemicals and cancer risk: A systematic review

Environmental risks are responsible for one in five of all deaths worldwide. Persistent, bioaccumulative, and toxic substances are chemicals that can subsist for decades in human tissues and the environment. They include heavy metals, organochlorines, polychlorinated biphenyls, organobromines, organofluorines, and polycyclic aromatic hydrocarbons among others. Although humans are often exposed to multiple pollutants simultaneously, their…

Relationship between physical activity and weight status in adults: a multinomial hierarchical analysis

Se observa una asociación inversa significativa entre la actividad física y la obesidad Obesity, which in itself is a long-term disease, is at the same time a risk factor in the development of serious pathologies such as ischaemic heart disease, hypertension, hypercholesterolaemia and respiratory insufficiency.1 In developed countries, the prevalence of this disease has risen…