Sustained Negative Mental Health Outcomes Among Healthcare Workers Over the First Year of the COVID-19 Pandemic: A Prospective Cohort Study

Objective: To characterize the evolution of healthcare workers’ mental health status over the 1-year period following the initial COVID-19 pandemic outbreak and to examine baseline characteristics associated with resolution or persistence of mental health problems over time. Methods: We conducted an 8-month follow-up cohort study. Eligible participants were healthcare workers working in Spain. Baseline data…

Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Background: The consumption of sweet beverages has been associated with greater risk of type 2 diabetes and obesity, which may be involved in the development of pancreatic cancer. Therefore, it has been hypothesized that sweet beverages may increase pancreatic cancer risk as well. Objective: We examined the association between sweet-beverage consumption (including total, sugar-sweetened, and…

Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort: a dietary pattern approach

Background Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods This investigation included 450,064 adults from the European…

Syncope and bifascicular block in the absence of structural heart disease

The treatment of patients with bifascicular block (BFB) and syncope in the absence of structural heart disease (SHD) is not well defined. The objective of our study is to compare pacemaker empirical implantation with the use of electrophysiological studies (EPS). This is a prospective cohort study that included 77 patients with unexplained cardiogenic syncope and BFB without structural…

Systematic Review of the Effect of Adherence to Statin Treatment on Critical Cardiovascular Events and Mortality in Primary Prevention

Aim: Analyze the relative risks of critical cardiovascular outcomes and mortality associated with adherence to statin treatment in a clinical setting in people with no history of prior cardiovascular disease (CVD). Methods: A systematic review of the literature was conducted up to December 2016. The outcomes of interest were cardiovascular fatal or nonfatal events and…

Systematic reviews on neurodevelopmental and neurodegenerative disorders linked to pesticide exposure: Methodological features and impact on risk assessment

Background Epidemiological data are not currently used in the risk assessment of chemical substances in a systematic and consistent manner. However, systematic reviews (SRs) could be useful for risk assessment as they appraise and synthesize the best epidemiological knowledge available. Objectives To conduct a comprehensive literature search of SRs pertaining to pesticide exposure and various…

Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study

Background The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not differentiated between high-grade or advanced stage tumours, but rather have assessed risk with a combined category of aggressive disease. We investigated the association of height and adiposity with incidence of…

Targeted maximum likelihood estimation for a binary treatment: A tutorial

When estimating the average effect of a binary treatment (or exposure) on an outcome, methods that incorporate propensity scores, the G‐formula, or targeted maximum likelihood estimation (TMLE) are preferred over naïve regression approaches, which are biased under misspecification of a parametric outcome model. In contrast propensity score methods require the correct specification of an exposure…

Tecnologías de la información en la gestión del conocimiento en el ámbito hospitalario

Los sistemas operacionales o transaccionales han permitido hacer más eficientes las organizaciones, capacitándolas para procesar un enorme volumen de transacciones de manera óptima, mejorando así la logística, el tratamiento de la información y prestando un mejor servicio al ciudadano. Esta publicación de 2004 venía a llenar un vacío en lengua española sobre estos temas, estableciendo…

Tendencia de la obesidad infantil y el bajo peso por año de nacimiento y edad en España, 1983-2011

Introducción y objetivos Las prevalencias de obesidad infantil y sobrepeso están en aumento en todo el mundo y representan un importante problema de salud pública, especialmente en los perfiles de riesgo cardiovascular en la edad adulta si la obesidad no se revierte. La identificación precisa de las tendencias y los subgrupos en riesgo es crucial…