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Polymorphisms of pesticide-metabolizing genes in children living in intensive farming communities

Artículos Científicos

Polymorphisms in genes encoding xenobiotic-metabolizing enzymes (XME) are important parameters accounting for the wide inter-individual variability to environmental exposures. Paraoxonase-1 (PON1), butyrylcholinesterase (BChE) and Cytochrome-P450 constitute major classes of XME involved in the detoxification of pesticide chemicals, in particular organophosphates. This study explored the allelic frequency, linkage disequilibrium and haplotype analysis of ten common polymorphic…

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Controversial messages on cancer

Artículos Científicos

A direct connection between certain lifestyle factors and an increased risk of cancer has already been established. Despite well-documented associations, controversial messages on causes of cancer often appear without taking into consideration their impact on the general population. While mainstream coverage of cancer research is clearly welcome, consideration must be given to the risk of…

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Main nutrient patterns are associated with prospective weight change in adults from 10 European countries

Artículos Científicos

Purpose Various food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults. Methods This study includes 235,880 participants, 25–70 years old, recruited between 1992 and 2000 in 10 European countries.…

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Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study

Artículos Científicos

Background: Results from several cohort and case–control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered. Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in…

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Necesidad de la perspectiva de género en el anuario de Anales de Pediatría

Artículos Científicos, Género y Salud

Sra. Editora: Gracias al editorial publicado en junio: «El espacio de los editores: anuario de Anales de Pediatría»1, hemos conocido el balance anual de esta revista. El proceso de evaluación de las revistas científicas es una actividad fundamental para mejorar la calidad y transparencia de sus contenidos. Con la intención de enriquecer este ejercicio de…

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Trends in survival of multiple myeloma: a thirty-year population-based study in a single institution

Artículos Científicos

Background: Despite the progress made in recent years, multiple myeloma is still considered an incurable disease. Most survival data come from clinical trials. Little is known about the outcome in unselected real-life patients. Methods:Overall survival was analyzed in a cohort of newly diagnosed symptomatic multiple myeloma patients, over the last three decades, in a single…

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Nutrient Patterns and Their Food Sources in an International Study Setting: Report from the EPIC Study

Artículos Científicos

Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses. We identified nutrient patterns from food frequency questionnaires (FFQ) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study and used 24-hour…

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Preoperative use of statins does not improve outcomes and development of acute renal failure after cardiac surgery. A propensity score analysis of ARIAM-Andalucía database

Artículos Científicos

Statin use prior to cardiac surgery has been reported to improve outcomes in the postoperative period because of other effects apart from decreasing lipid levels. Objective of the study was to analyse mortality and acute renal failure (ARF) during the cardiac surgery postoperative period in patients treated with or without statins. METHODS: This prospective cohort…

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Alteration of Amino Acid and Biogenic Amine Metabolism in Hepatobiliary Cancers: Findings from a Prospective Cohort Study

Artículos Científicos

Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary tract (GBTC). Circulating standard AA,…