Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study

Background:The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective:To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design:Prospective cohort study. Setting:10 European countries. Participants:521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements:Hazard ratios (HRs) and 95% CIs estimated…

Health assessments for health governance: concepts and methodologies

Background: For better supporting the science-governance interface, the potential of health assessments appears underrated. Aims: To identify what various types of health assessment have in common; how they differ; which assessment(s) to apply for which purpose; and what needs and options there are for future joint development. Methods: This review is based on five types…

Hospital admissions due to alcohol related disorders among young adult refugees who arrived in Sweden as teenagers – a national cohort study

Background Psychological distress and lack of family support may explain the mental health problems that are consistently found in young unaccompanied refugees in Western countries. Given the strong relationship between poor mental health and alcohol misuse, this study investigated hospital admissions due to alcohol related disorders among accompanied and unaccompanied young refugees who settled in…

Unlocking the potential of established products: toward new incentives rewarding innovation in Europe

Background: Many established products (EPs – marketed for eight years or more) are widely used off-label despite little evidence on benefit–risk ratio. This exposes patients to risks related to safety and lack of efficacy, and healthcare providers to liability. Introducing new indications for EPs may represent a high societal value; however, manufacturers rarely invest in R&D…

Evaluación de las prescripciones fuera de ficha técnica: perfil, evidencia y evolución

Objetivo: Los objetivos del estudio fueron describir la magnitud y el perfil de las prescripciones fuera de ficha técnica (off-label), evaluar el nivel de evidencia en el que se sustentan estas indicaciones, valorar la actividad investigadora en estas enfermedades y determinar en qué grado se autorizan como nuevas indicaciones transcurridos cinco años desde la solicitud. Métodos: Estudio transversal que incluyó…

Nut intake and 5-year changes in body weight and obesity risk in adults: results from the EPIC-PANACEA study

Purpose There is inconsistent evidence regarding the relationship between higher intake of nuts, being an energy-dense food, and weight gain. We investigated the relationship between nut intake and changes in weight over 5 years. Methods This study includes 373,293 men and women, 25–70 years old, recruited between 1992 and 2000 from 10 European countries in the European…