{"id":190,"date":"2022-10-19T10:51:34","date_gmt":"2022-10-19T10:51:34","guid":{"rendered":"https:\/\/www.easp.es\/web\/geneida\/?p=190"},"modified":"2022-10-19T13:43:58","modified_gmt":"2022-10-19T11:43:58","slug":"news-tobacco-use-during-pregnancy-may-affect-placental-dna-and-cause-adverse-effects-on-foetal-growth","status":"publish","type":"post","link":"https:\/\/www.easp.es\/web\/geneida\/en\/news-tobacco-use-during-pregnancy-may-affect-placental-dna-and-cause-adverse-effects-on-foetal-growth\/","title":{"rendered":"[NEWS] Tobacco use during pregnancy may affect placental DNA and cause adverse effects on foetal growth"},"content":{"rendered":"
[vc_row][vc_column][vc_column_text]\r\n\r\nThe Andalusian School of Public Health coordinates one of the 7 epidemiological projects included in the study published<\/a> by the prestigious journal Nature Communications in which 5 countries participate.<\/strong>\r\n\r\nThe results of the research in which the Andalusian School of Public Health (EASP), an entity of the Regional Ministry of Health and Families, is participating, show an association between tobacco consumption during pregnancy, epigenetic changes in placental DNA and the negative impact on foetal growth<\/strong>.\u00a0The study<\/a> has also advanced scientific knowledge on the mechanisms through which this exposure to tobacco impairs placental function and, therefore, foetal growth.\r\n\r\nThe epigenetic mechanism analysed corresponds to small chemical modifications that are added to or eliminated from DNA<\/strong>, without modifying its basic sequence, in response to environmental exposures, such as tobacco. These variations can alter the regulation of gene expression, in this case of those involved in the correct functioning of the placenta, whose possible alteration due to smoking can cause adverse<\/strong> effects on foetal growth.\r\n\r\nThe study<\/a> involved 1,700 mother\/child pairs from seven population groups from Europe, North America and Australia<\/strong>, within the framework of the international consortium on Pregnancy And Childhood Epigenetics (PACE) This study has integrated data from the Andalusian research project GENEIDA, whose main objective is to study the effects of early environmental exposures on the origin of human diseases throughout life, evaluating potential genetic and epigenetic mechanisms.\r\n

GENEIDA (Genetics, ENvironmental Exposures and Infant Development in Andalusia)<\/strong><\/h3>\r\nAmong the population groups selected for this study are the mother\/child pairs participating in the GENEIDA (Genetics, ENvironmental Exposures and Infant Development in Andalusia) project – https:\/\/www.easp.es\/web\/geneida<\/a> -, of which 5 researchers are co-authors of the above-mentioned study.\r\n\r\nThe main objective of GENEIDA is to contribute to improve scientific knowledge on the effect of adverse exposures: environmental toxic compounds, nutrition, psychological and social stress, maternal diseases, as well as genetic and epigenetic factors; during pregnancy, childhood and adolescence in the development of diseases throughout life.\r\n\r\nThe knowledge generated by this research is intended to help protect the health of pregnant women and their offspring during childhood and adolescence, and to prevent diseases that may develop during adulthood<\/strong>.\r\n\r\nThe GENEIDA project is led by EASP professor Marina Lacasa\u00f1a, and researchers from the EASP, the Centre for Genomics and Oncology Research (GENYO) in Granada, the Institute for Biosanitary Research of Granada (ibs.GRANADA), the University of Granada, CIBER of Epidemiology and Public Health (CIBERESP), and health professionals from the Hospital de Poniente (Almeria) are working on it.\r\n

Epigenetic studies<\/strong><\/h3>\r\nEpigenetic studies are providing scientific knowledge about the regulation of gene expression, identifying genetic and environmental<\/strong> interactions in the determination of the phenotype.\r\n\r\nThe identification of mechanisms that regulate gene expression without a change in DNA sequence may provide scientific insight into the effect of environmental exposures on phenotype determination.\r\n

Nature Communications<\/strong><\/h3>\r\nNature Communications is a peer-reviewed, open access scientific journal. The journal disseminates research of high scientific quality that represents an important advance in scientific knowledge in the different fields of Natural Sciences.\r\n\r\nThe journal is available in health research reference indexes, such as DOAJ, MEDLINE, Web of Science, Scopus and Google Scholar.\r\n

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