Background Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective Investigation into Cancer…
Background Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach, we prospectively investigated the associations between metabolite concentrations in plasma and breast cancer risk. Methods A nested case-control study was established within the European Prospective Investigation into Cancer cohort, which included 1624 first primary incident invasive…
Objetivo Identificar las fortalezas disponibles para la orientación comunitaria de la atención primaria de salud (APS) en el contexto de la evaluación del pilotaje de un programa formativo en salud comunitaria para especialistas internos residentes en Andalucía. Método Estudio cualitativo explicativo de diseño fenomenológico, en el que se analiza la opinión de las personas participantes,…
Antecedentes: las acciones de promoción de la salud permiten abordar la injusticia de vivir en lugares no suficientemente dignos para ser habitados. Sin embargo, existen pocas metodologías que describan cómo realizar una evaluación externa en intervenciones de promoción de la salud desde una perspectiva de regeneración comunitaria en estos contextos. Objetivo: presentar un proceso de…
La incorporación del modelo de activos para la salud en las intervenciones de salud comunitaria/promoción de la salud puede reforzar aspectos relacionados con la equidad, la orientación a los determinantes sociales, la intersectorialidad y la participación en dichas intervenciones.
Background: Experimental and epidemiologic data suggest that higher circulating prolactin is associated with breast cancer risk; however, how various risk factors for breast cancer influence prolactin levels in healthy women is not clear. Methods: We analyzed cross-sectional associations between several suggested reproductive and lifestyle risk factors for breast cancer and circulating prolactin among pre- and…
Background Within (European) healthcare systems, the predominant goal for pharmaceutical expenditure is cost containment. This is due to a general belief among healthcare policy makers that pharmaceutical expenditure—driven by high prices—will be unsustainable unless further reforms are enacted. Objective The aim of this paper is to provide more realistic expectations of pharmaceutical expenditure for all…
The study aims to assess the implementation of tobacco control policies in Mexico from 2003 through 2017 using the Tobacco Control Scale (TCS). The TCS is a research tool widely used in the European region. It facilitates assessment of tobacco control policy implementation based on six cost-effective interventions: tobacco taxes, smoke-free policies, advertising bans, public…
Background Inflammation influences tumour progression and cancer prognosis, but its role preceding breast cancer (BC) and its prognostic implications remain inconclusive. Methods We studied pre-diagnostic plasma inflammatory biomarkers in 1538 women with BC from the EPIC study. Cox proportional hazards models assessed their relationship with all-cause and BC-specific mortality, adjusting for tumour characteristics and lifestyle…
Background Head and neck (H&N) cancers are a heterogeneous group of malignancies, affecting various sites, with different prognoses. The aims of this study are to analyse survival for patients with H&N cancers in relation to tumour location, to assess the change in survival between European countries, and to investigate whether survival improved over time. Methods…
