Boletines serie infografías cáncer
Background One-carbon metabolism (1CM) regulates critical processes in carcinogenesis. However, the influence of 1CM-related nutritional and genetic factors on breast cancer (BC) risk remains unclear. Objectives This study aimed to assess the impact of 1CM-related nutrients and genetic variants with BC risk. Methods Case-control study nested within the European Prospective Investigation into Cancer and Nutrition…
The ‘European Prospective Investigation into Cancer and Nutrition’ cohort (EPIC) is a prospective study including ~ 520,000 participants recruited across Europe (1991–2000) with in-depth baseline data on nutritional, lifestyle, medical, and anthropometric variables, and baseline blood samples. Here we introduce EPIC4ND, a case-cohort study within EPIC designed to identify biomarkers predicting a future onset of dementia, Alzheimer’s…
Background and objective Plant-based diet (PBD) followers are growing worldwide. The aim was to explore the dietary profile of PBDs, taking the omnivorous (OMN) diet as a reference. Methods A cross-sectional study was carried out. A total of 760 participants were included, of whom 161 self-identified as vegan, ovo-lacto-vegetarian, or pesco-vegetarian. Intakes of 175 foods,…
Emerging evidence links consumption of ultra-processed foods (UPF) to higher risks of non-communicable diseases and mortality, but the underlying mechanisms remain unclear. This study aimed to identify molecular signatures of UPF intake in participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Foods were classified into four groups using the Nova system,…
The immune system is a major driver in pancreatic cancer development. Several prospective cohort studies have found associations for single immune system-derived proteins such as IL6 or CRP, but results are inconclusive, and Omics-based research is scarce. Hence, we aimed to investigate associations of a comprehensive protein panel with the risk of pancreatic cancer. Within…
Introduction There is growing concern about rising cancer incidence among adults younger than 50 years. This collaborative study within the Spanish Network of Cancer Registries (REDECAN) aimed to examine cancer incidence trends in young adults in Spain. Material and methods This population-based observational study used data from 15 cancer registries. All newly diagnosed cancer cases…
Organized breast cancer screening programmes are a cornerstone of cancer control policy across Europe. Population-based cancer registries (PBCRs) play a central role in monitoring screening performance, outcomes, and programme quality. However, the extent and methodological approaches of registry-based evaluations across Europe have not been comprehensively synthesized. Following PRISMA-ScR guidelines, we conducted a scoping review of…
Background The incidence of early-onset cancers (EOCs), defined as cancers diagnosed before 50 years of age, has risen globally over the past three decades. The association between modifiable lifestyle factors and EOC risk has been poorly investigated. Methods Participants enrolled before age 50 in EPIC (39,459 men; 110,991 women) and the UK Biobank (52,188 men;…
Purpose To investigate socio-economic disparities in the association between dietary diversity and type 2 diabetes (T2D). Methods Prospective secondary analysis study of 10,363 incident cases of T2D over 12 years and a random sub-cohort of 13,937 individuals in the EPIC-InterAct case-cohort study. We used baseline self-reported diet data (1991–1998) to construct scores for diversity between food…
Background: Low socio-economic status (SES) is considered a major chronic stressor and is frequently associated with worse mental health among cancer survivors. We investigated the extent to which social support could mitigate the negative impact of low SES on the mental health of individuals with a history of cancer. Method: Participants were cancer survivors identified…
