Anticipated help-seeking for cancer symptoms before and after the coronavirus pandemic: results from the Onco-barometer population survey in Spain

Background The patient interval—the time patients wait before consulting their physician after noticing cancer symptoms—contributes to diagnostic delays. We compared anticipated help-seeking times for cancer symptoms and perceived barriers to help-seeking before and after the coronavirus pandemic. Methods Two waves (pre-Coronavirus: February 2020, N = 3269; and post-Coronavirus: August 2020, N = 1500) of the Spanish Onco-barometer population survey were compared.…

Soft drink and juice consumption and renal cell carcinoma incidence and mortality in the European Prospective Investigation into Cancer and Nutrition

Background: Renal cell carcinoma (RCC) accounts for more than 80% of kidney cancers in adults and obesity is a known risk factor. Regular consumption of sweetened beverages has been linked to obesity and several chronic diseases including some types of cancer. It is uncertain whether soft drink and juice consumption is associated with risk of…

A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Background Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5′-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in…

Self-Perceived Health, Life Satisfaction and Related Factors among Healthcare Professionals and the General Population: Analysis of an Online Survey, with Propensity Score Adjustment

Healthcare professionals (HCPs) often suffer high levels of depression, stress, anxiety and burnout. Our main study aimswereto estimate the prevalences of poor self-perceived health, life dissatisfaction, chronic disease and unhealthy habits among HCPs and to explore the use of machine learning classification algorithms to remove selection bias. A sample of Spanish HCPs was asked to…

Dietary intake of trans fatty acids and breast cancer risk in 9 European countries

Background Trans fatty acids (TFAs) have been hypothesised to influence breast cancer risk. However, relatively few prospective studies have examined this relationship, and well-powered analyses according to hormone receptor-defined molecular subtypes, menopausal status, and body size have rarely been conducted. Methods In the European Prospective Investigation into Cancer and Nutrition (EPIC), we investigated the associations…

Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism and Infant’s Anthropometry at Birth

Identification of causal factors that influence fetal growth and anthropometry at birth is of great importance as they provide information about increased risk of disease throughout life. The association between maternal genetic polymorphism MTHFR(677)C>T and anthropometry at birth has been widely studied because of its key role in the one-carbon cycle. MTHFR(677) CT and TT…

Plasma concentrations of advanced glycation end-products and colorectal cancer risk in the EPIC study

Advanced glycation end-products (AGEs) are a heterogeneous group of compounds formed by the non-enzymatic reaction between amino-acids and reducing sugars, or dicarbonyls as intermediate compounds. Experimental studies suggest that AGEs may promote colorectal cancer, but prospective epidemiologic studies are inconclusive. We conducted a case-control study nested within a large European cohort. Plasma concentrations of three…

Socioeconomic Inequalities and Ethnicity Are Associated with a Positive COVID-19 Test among Cancer Patients in the UK Biobank Cohort

We explored the role of socioeconomic inequalities in COVID-19 incidence among cancer patients during the first wave of the pandemic. We conducted a case-control study within the UK Biobank cohort linked to the COVID-19 tests results available from 16 March 2020 until 23 August 2020. The main exposure variable was socioeconomic status, assessed using the…

COVID-19 y dependencia funcional: análisis de un brote en un centro sociosanitario de personas mayores.

Fundamentos: Los mayores institucionalizados han sido el grupo más afectado por la pandemia de COVID-19. El objetivo del presente estudio fue describir las principales características epidemiológicas de un brote de COVID-19, detectado en marzo 2020 en una residencia para mayores de Granada, e identificar los factores de riesgo asociados a la propagación del virus en…

Combined Genome, Transcriptome and Metabolome Analysis in the Diagnosis of Childhood Cerebellar Ataxia

Ataxia in children is a common clinical sign of numerous neurological disorders consisting of impaired coordination of voluntary muscle movement. Its most common form, cerebellar ataxia, describes a heterogeneous array of neurologic conditions with uncountable causes broadly divided as acquired or genetic. Numerous genetic disorders are associated with chronic progressive ataxia, which complicates clinical management,…