LupaDetalles

A prospective study of physical activity and cardiometabolic diseases in association with cancer risk

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Most physical activity research focuses on general populations, and its cancer-preventive benefits in adults with cardiometabolic diseases remain poorly understood. This study investigated associations between non-occupational physical activity and cancer risk in adults with and without cardiometabolic diseases (cardiovascular disease and/or type 2 diabetes). Methods We conducted a meta-analysis of individual participant data of…

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Sociodemographic and residential characteristics associated to persistent and non-persistent organic pollutants in household dust from Southern Spain. COVID-AND Study

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Background Scientific evidence suggests that indoor dust contains chemical pollutants, such as per- and polyfluoroalkyl substances (PFAS), bisphenols, parabens, and benzophenones, which are present in building materials and everyday products and could have implications for human health. Objective To quantify levels of PFAS, bisphenols, parabens, and benzophenones in household dust of four cohorts from Andalusia…

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Meat Intake and Risk of Gastric and Esophageal Adenocarcinoma in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Whether meat consumption increases the risk of gastric cancer (GC) and esophageal cancer or not remains unclear. Moreover, the number of prospective studies evaluating the associations by anatomical and histological types of GC is limited. We aimed to assess the associations of red, processed, and white meat with all gastric adenocarcinomas by anatomical site and…

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Linking Nutri-Score dietary profiles to metabolic biomarkers in a cross-sectional study within the multinational EPIC cohort

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

The front-of-pack label Nutri-Score has been implemented in several European countries since 2017 to guide consumers towards foods of higher nutritional value. A few studies reported associations between Nutri-Score dietary profiles reflecting a lower nutritional quality, however not using the 2023-updated version of the algorithm, and profiles of biomarkers consistent with increased metabolic risk. Our…

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Mapping the landscape of managed entry agreements: a systematic review of global frameworks, system-level components, and implementation challenges

Artículos Científicos, Investigación

Background: Managed Entry Agreements (MEAs) are pivotal for enabling access to innovative pharmaceuticals while mitigating financial risk and addressing evidence uncertainty. Despite conceptual acceptance, the essential requirements for their design and implementation are poorly documented, posing a challenge for evolving health systems. This study aimed to systematically review and map global evidence published in the…

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A data-driven framework for predicting PEG-defined MacroB12 in hypercobalaminemia

Cáncer, Investigación

MacroB12 interference presents a significant challenge in the diagnosis of Vitamin B12 status, potentially masking true deficiency. To establish robust predictors and quantify the utility of pre-polyethene glycol (PEG) B12 levels, we conducted a retrospective analysis of 875 individuals with hypercobalaminemia (>1000 pg/mL), using multiple imputation to handle missing data. Multivariable regression modelling revealed that PEG-defined…

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Assessing the role of ultra-processed foods in colorectal cancer incidence: insights from the EPIC cohort

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Studies have reported associations between ultra-processed food (UPF) consumption and colorectal cancer (CRC) incidence, yet the magnitude of these associations remains unclear. This study estimated the cohort-associated fraction (CAF), adapted from the population-attributable fraction metric, between UPF consumption and CRC incidence and explored the potential benefits of substituting UPFs with unprocessed or minimally processed…

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Premenopausal and postmenopausal obesity and endometrial cancer risk: circulating biomarkers of inflammation, insulin resistance, and sex hormones as mediators

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Obesity may increase endometrial cancer risk through pathways involving chronic inflammation, insulin resistance, and altered sex hormone levels. Methods Within the European Prospective Investigation into Cancer and Nutrition cohort, we investigated these mediating pathways using prediagnostic circulating biomarkers measured in 337 matched case-control pairs with postmenopausal measurements and 196 pairs with premenopausal measurements. We…

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Intake of the Total, Classes, and Subclasses of (Poly)phenols and Breast Cancer Risk: A Prospective Analysis of the EPIC Study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Polyphenols represent the largest and most diverse class of dietary antioxidants. Epidemiological evidence linking specific (poly)phenol classes, such as flavonoids and lignans, to breast cancer (BC) risk remains limited and largely inconclusive in prospective studies. The aim of this study is to examine the association between the intake of total (poly)phenols—and its classes and subclasses—and…

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Associations between dietary exposure to dioxins and polychlorinated biphenyls (PCBs) and Longitudinal changes in weight and waist circumference– an EPIC study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background: Obesity is a growing global health concern. Some evidence suggests that exposure to polychlorinated biphenyls (PCBs) and dioxins, may play a role in weight gain, but human prospective data are limited and have shown inconsistent results. Therefore, this study investigate the association between dietary exposure to dioxins and PCBs and changes in weight and…