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Identification and prioritisation of biomarkers of organophosphorus compounds-induced neurotoxicity

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Organophosphorus compounds (OPCs), a diverse group of chemicals widely utilised as pesticides and flame retardants, pose significant neurotoxic risks, even during neurodevelopment. While their primary molecular and cellular targets are well characterised, growing evidence suggest additional mechanisms, particularly in developmental neurotoxicity. Despite extensive research, predictive biomarkers of OPC-induced neurotoxicity beyond acetylcholinesterase remain underexplored. This study…

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Dietary and lifestyle determinants of vitamin D status in the UK Biobank Cohort study for predictive modeling

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Vitamin D (VD) is involved in a wide variety of physiological processes. The high prevalence of VD deficiency in the population requires stronger preventive measures. Objective Characterize the dietary and lifestyle determinants of VD levels in blood and of VD deficiency to further develop predictive models of these two outcomes. Methods 63,759 participants from…

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Correlation between tobacco control policies and the smoking behaviors of European adolescents from 2005 to 2019

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Despite legislative efforts, tobacco smoking prevalence among European adolescents remains high and heterogeneous between countries. While tobacco control policies, often assessed using Tobacco Control Scale (TCS), have been studied in adults, their influence on preventing adolescent smoking initiation remains unknown. This ecological study investigates the correlation between tobacco control policies implementation and adolescents smoking behavior…

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Examining causal relationships between educational attainment and type 2 diabetes using genetic analysis: findings from the EPIC-InterAct study through Mendelian randomisation

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Introduction Observational studies have shown that more educated people are at lower risk of developing type 2 diabetes (T2D). However, robust study designs are needed to investigate the likelihood that such a relationship is causal. This study used genetic instruments for education to estimate the effect of education on T2D using the Mendelian randomisation (MR)…

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Evaluating SinergiAPS, an intervention based on patient feedback to improve patient safety in primary care: a cluster randomized trial

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Background Patient safety, defined by the WHO as the absence of preventable harm, is a critical component of healthcare quality and poses a significant challenge globally. This study aimed to evaluate the effectiveness of SinergiAPS, a patient-centred audit and feedback intervention, in improving patient safety in primary healthcare (PHC) centres. Methods We conducted a 12-month…

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Clinical effects of probiotics on the treatment of gingivitis and periodontitis: a systematic review and meta-analysis

Artículos Científicos, Investigación

Aims This study aimed to evaluate the impact of probiotics as an adjunct to periodontal therapy on clinical outcomes in patients with gingivitis and periodontitis through a meta-analysis of available evidence. Materials and methods A detailed bibliographic search on four databases (PubMed, Scopus, Cochrane and EMBASE) was conducted with a language restriction. The collected data…

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Prospective evaluation of 92 protein biomarkers for early detection of endometrial cancer

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

The human epididymis protein 4 (HE4) remains the best available endometrial cancer (EC) biomarker; however, its discrimination between cases and cancer-free individuals is limited and might be improved when combined with other protein markers. We evaluated the discrimination capacity of 92 proteins as potential early detection biomarkers for EC in nested case–control studies in the…

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Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background: Current evidence suggests higher physical activity (PA) levels are associated with a reduced risk of colorectal cancer. However, the mediating role of the circulating metabolome in this relationship remains unclear. Methods: Targeted metabolomics data from 6,055 participants in the European Prospective Investigation into Cancer and Nutrition cohort were used to identify metabolites associated with…

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Retraso en el acceso al primer tratamiento para la adicción en usuarios de opiáceos

Artículos Científicos, Investigación

La búsqueda temprana de tratamiento para la adicción a los opiáceos se relaciona con un aumento de las posibilidades de éxito en el mismo. Los nuevos pacientes que buscan este tratamiento, y el tiempo que tardan en demandarlo, han sido escasamente descritos en España y Europa. El objetivo del presente estudio es identificar los factores…

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Education level and risk of breast cancer by tumor subtype in the EPIC cohort

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Breast cancer (BC) is a heterogeneous disease with subtypes based on receptor status (estrogen receptor [ER], progesterone receptor [PR], and human epidermal growth factor receptor 2 [HER2]), influencing prognosis and treatment. A higher socioeconomic position (SEP) is associated with an increased BC risk, but its relation to BC subtypes is less clear. This study analyzed…