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Trends in endpoint selection and result interpretation in advanced non‐small cell lung cancer clinical trials published between 2000 and 2012: A retrospective cohort study

Artículos Científicos

Background The objective of this review was to investigate trends in clinical trial design, specifically, the primary outcomes used, interpretation of results, and the magnitude of the benefits described in phase III controlled clinical trials in the first‐line treatment of patients with advanced non‐small cell lung cancer (NSCLC). Methods Seventy‐six trials published between 2000 and…

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Trends in cutaneous malignant melanoma incidence, mortality and survival over three decades: a population-based study in Southern Spain

Cáncer, Igualdad, Investigación, Mujeres EASP

Background Cutaneous malignant melanoma (CMM) represents a global public health problem. Epidemiological studies about CMM trends tend to focus on single indicators or lack information about tumour characteristics that can help gain a more thorough understanding of CMM epidemiology. Objectives To fill this gap, we studied CMM trends in incidence, mortality and survival over three…

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Treatment choice in the presence of conflicting information: The role of physician likeability in the choice of non-proven therapies against conventional treatment

Artículos Científicos

Research on why patients sometimes choose non-proven therapies (NPT) instead of conventional treatments is limited. We investigated how physician likeability influences the choice of NPT instead of conventional treatment. In an experiment with three medical scenarios, participants (N = 384) consulted two physicians who gave conflicting recommendations: The first physician recommended a conventional treatment and the second…

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Transdisciplinariedad efectiva en el cuidado de la diabetes: Diagnóstico PRECEDE

Artículos Científicos

La diabetes mellitus (DM) es una enfermedad compleja y multifactorial que requiere un proceso integrado de actividades y diferentes niveles de medición de resultados1. El cuidado transdisciplinario (CTD) es la prestación conjunta que asocia diferentes entornos y disciplinas con interacciones continuas entre el sistema de salud y social en los que cada persona está inmersa…

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Transcriptomic profiling unveils novel therapeutic options for drug-resistant temporal lobe epilepsy

Artículos Científicos

Background Epilepsy drug treatments fail in 25–30 % of patients, leading to drug resistance. Temporal lobe epilepsy is the most prevalent subtype associated with drug resistance. Classical drug discovery is a long and extremely costly process with a high failure rate in clinical trials. Drug repurposing is a more cost- and time-effective strategy. Hence, the main…

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Trabajo nocturno por turnos y el riesgo de cáncer de mama y próstata: actualizando la evidencia a partir de estudios epidemiológicos

Artículos Científicos

Resumen   Se ha formulado la hipótesis de que la disrupción circadiana está relacionada con un mayor riesgo de cáncer. Desde que la Agencia Internacional de Investigación sobre el Cáncer clasificó la disrupción circadiana asociada al trabajo por turnos como “probablemente carcinógeno para los humanos” (Grupo 2A) se han llevado a cabo numerosos estudios para…

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Towards a taxonomy of judicialisation for access to medicines in Latin America

Artículos Científicos

In Latin America, ‘judicialization’ for access to healthcare refers to thousands of different claims, conditions, technologies and circumstances. Its impact depends on what is ‘judicialized’, why, for which benefit, and at what cost to society. Since judges cannot, by themselves, reduce medical uncertainty – or price tags – their health systems are exposed to costly…

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Timing of eating across ten European countries – results from the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study

Artículos Científicos

Objective: To examine timing of eating across ten European countries. Design: Cross-sectional analysis of the European Prospective Investigation into Cancer and Nutrition (EPIC) calibration study using standardized 24 h diet recalls collected during 1995–2000. Eleven predefined food consumption occasions were assessed during the recall interview. We present time of consumption of meals and snacks as…

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Tiered Pricing and Alternative Mechanisms for Equitative Access to Vaccines in Latin America: A Narrative Review of the Literature

Artículos Científicos, Investigación

Methods We conducted a narrative review to explore and describe alternatives for equitable vaccine access in Latin America. We searched and considered the main access strategies reported in the literature through PubMed, Science Direct, and Google Scholar. Additionally, we reviewed the web sites of key stakeholders. The search was conducted using the following keywords: (“access”…