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Propuesta de metodología cualitativa para la valoración externa de un proyecto basado en el desarrollo de activos comunitarios

Artículos Científicos

Antecedentes: las acciones de promoción de la salud permiten abordar la injusticia de vivir en lugares no suficientemente dignos para ser habitados. Sin embargo, existen pocas metodologías que describan cómo realizar una evaluación externa en intervenciones de promoción de la salud desde una perspectiva de regeneración comunitaria en estos contextos. Objetivo: presentar un proceso de…

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Impact of Pharmacogenetics on High-Dose Methotrexate Toxicity in Pediatric Oncology

Artículos Científicos, Cáncer

Background: Childhood cancers represent a heterogeneous group of malignancies and remain one of the leading causes of mortality among children under 14 years of age, ranking second only to accidental injuries, and fourth among individuals aged 15 to 19 years. Despite notable improvements in cure rates, a substantial proportion of patients experience acute or long-term…

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The still incomplete pursuit of universal access to medicines

Artículos Científicos

A substantial share of the global population continues to face barriers to accessing essential medicines. While the pharmaceutical industry’s business model has successfully facilitated the development of innovative medications, efforts to promote universal access to medicines (UAM) remain ineffective. This paper critically assesses the existing barriers to global access to medicines, including the role of…

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A strategic framework for synergizing managed entry agreement efforts to access pharmaceutical products in Saudi Arabia—results from a multi-stakeholder workshop

Artículos Científicos

Background Managed entry agreements (MEAs) between manufacturers and healthcare payers allow health systems to maximize patients’ access to treatments while maintaining financial sustainability. However, to work efficiently, MEAs need to be integrated into a country’s formal pricing, reimbursement, and market access processes. This study proposes a country-specific MEA framework for pharmaceutical products and sheds light…

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Trends in the incidence of brain cancer and the use of mobile phones: analysis of the Spanish Network of Cancer Registries (REDECAN)

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Purpose The association between the use of mobile phones use and the risk of brain cancer remains controversial. The aim of this study is to describe trends in the incidence of central nervous system (CNS) cancers in Spain and its possible relationship with mobile phone use. Methods Trends and trend changes from 1985 to 2015…

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Cohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses)

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

The CORDELIA Study (Collaborative Cohorts Reassembled Data to Study Mechanisms and Long-term Incidence of Chronic Diseases) combines 35 Spanish population cohorts to investigate the clinical, environmental, genetic, and omics determinants of cardiovascular disease in the Southern European population. It aims to conduct the largest genome-wide association study to date on cardiovascular disease in this population,…

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Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study

Artículos Científicos, Cáncer, Igualdad

Background & aims Circadian rhythms seem to impact both dietary intake and metabolism, depending on the individual’s chronotype. We aimed to explore whether the nutritional composition of meals throughout the day is influenced by genetics linked to the circadian clock and chronotype within the “European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet” study. Methods…

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Monitoring of the oncological process for lung cancer in Spain: an expert consensus report

Artículos Científicos

Introduction Continuous monitoring of the oncological process is essential for identifying inefficiencies and areas of improvement, enabling better resource allocation in the care of lung cancer patients. Objective The objective is to define key indicators and identify critical variables for monitoring lung cancer care, aiming to improve early detection, reduce delays in diagnosis and treatment,…

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Identification and prioritisation of biomarkers of organophosphorus compounds-induced neurotoxicity

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Organophosphorus compounds (OPCs), a diverse group of chemicals widely utilised as pesticides and flame retardants, pose significant neurotoxic risks, even during neurodevelopment. While their primary molecular and cellular targets are well characterised, growing evidence suggest additional mechanisms, particularly in developmental neurotoxicity. Despite extensive research, predictive biomarkers of OPC-induced neurotoxicity beyond acetylcholinesterase remain underexplored. This study…

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Molecular study of vitamin D metabolism-related single nucleotide polymorphisms in cardiovascular risk: a case-control study

Artículos Científicos

Cardiovascular diseases (CVDs) constitute a major global health problem, being the leading cause of death. Several risk factors for CVDs have been identified, including tobacco use, unhealthy diet, and physical inactivity. However, the role of genetic factors in CVDs remains unclear. Recent studies suggest that vitamin D deficiency is associated with an increased risk of…