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Examining causal relationships between educational attainment and type 2 diabetes using genetic analysis: findings from the EPIC-InterAct study through Mendelian randomisation

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Introduction Observational studies have shown that more educated people are at lower risk of developing type 2 diabetes (T2D). However, robust study designs are needed to investigate the likelihood that such a relationship is causal. This study used genetic instruments for education to estimate the effect of education on T2D using the Mendelian randomisation (MR)…

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Evaluating SinergiAPS, an intervention based on patient feedback to improve patient safety in primary care: a cluster randomized trial

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Background Patient safety, defined by the WHO as the absence of preventable harm, is a critical component of healthcare quality and poses a significant challenge globally. This study aimed to evaluate the effectiveness of SinergiAPS, a patient-centred audit and feedback intervention, in improving patient safety in primary healthcare (PHC) centres. Methods We conducted a 12-month…

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Prospective evaluation of 92 protein biomarkers for early detection of endometrial cancer

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

The human epididymis protein 4 (HE4) remains the best available endometrial cancer (EC) biomarker; however, its discrimination between cases and cancer-free individuals is limited and might be improved when combined with other protein markers. We evaluated the discrimination capacity of 92 proteins as potential early detection biomarkers for EC in nested case–control studies in the…

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Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background: Current evidence suggests higher physical activity (PA) levels are associated with a reduced risk of colorectal cancer. However, the mediating role of the circulating metabolome in this relationship remains unclear. Methods: Targeted metabolomics data from 6,055 participants in the European Prospective Investigation into Cancer and Nutrition cohort were used to identify metabolites associated with…

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Education level and risk of breast cancer by tumor subtype in the EPIC cohort

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Breast cancer (BC) is a heterogeneous disease with subtypes based on receptor status (estrogen receptor [ER], progesterone receptor [PR], and human epidermal growth factor receptor 2 [HER2]), influencing prognosis and treatment. A higher socioeconomic position (SEP) is associated with an increased BC risk, but its relation to BC subtypes is less clear. This study analyzed…

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Reassessing the association between age at menarche and cardiovascular disease: observational and Mendelian randomization analyses

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Aims Observational studies have shown a U-shaped association between age at menarche (AAM) and cardiovascular disease (CVD). We assessed non-linearity of the observational association and the potential causal relationship between AAM and CVD using data from the European Prospective Investigation into Cancer and Nutrition—Cardiovascular Disease (EPIC-CVD) study and the UK Biobank. Methods and results We…

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Sexual Dysfunction in Women With Eating Disorders: Systematic Review and Meta-Analysis

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Background Eating disorders (EDs) are common mental health conditions that impact people globally. Sexual health problems are also widely researched across various contexts. This paper explores the connection between these two areas by conducting a meta-analysis to assess sexual dysfunction (SD) in women with EDs compared to healthy individuals. Methods Multiple electronic databases were searched.…

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Inflammation and gut barrier function-related genes and colorectal cancer risk in western European populations

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Gut barrier dysfunction and related inflammation are known to be associated with the development and progression of colorectal cancer (CRC). We investigated associations of 292 single-nucleotide polymorphisms (SNPs) from 27 genes related to endotoxins/lipopolysaccharide (LPS) sensing and tolerance, mucin synthesis, inflammation, and Crohn’s disease with colon and rectal cancer risks. Incident CRC cases (N = 1374; colon = 871,…

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Comprehensive analysis of West Nile Virus transmission: Environmental, ecological, and individual factors. An umbrella review

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Background West Nile Virus (WNV) exemplifies the complexities of managing vector-borne diseases, expanding globally due to human activities and ecological changes. Originating from Africa and transmitted by Culex mosquitoes, WNV is now reported across multiple continents. The aim of this study was to identify the environmental, ecological, and individual factors influencing WNV transmission. Methods An…

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Higher intakes of dietary dicarbonyl compounds are associated with lower risk of cardiovascular disease

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Aims Dicarbonyl compounds such as methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG) are present in numerous foods. They are pro-inflammatory and pro-oxidative, but their potential role in cardiovascular disease (CVD) development has been scarcely studied. We explored associations between dietary dicarbonyls with fatal and non-fatal CVD. Methods and results We conducted a case-cohort analysis based…