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Assessing Organizational Readiness for Just Culture in Health Care

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Background: A Just Culture promotes fairness, accountability, and psychological safety in response to adverse events. Despite growing interest in its implementation, Spanish-speaking health care systems lack validated tools to assess organizational readiness. Objective: To develop and validate a Spanish-language instrument [Organizational Readiness for Just Accountability Scale (ORJA-S)] to assess health care professionals’ attitudes that reflect…

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Association between lifestyle and risk of early-onset cancer: Evidence from the European Prospective Investigation into Cancer and Nutrition and the UK Biobank

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background The incidence of early-onset cancers (EOCs), defined as cancers diagnosed before 50 years of age, has risen globally over the past three decades. The association between modifiable lifestyle factors and EOC risk has been poorly investigated. Methods Participants enrolled before age 50 in EPIC (39,459 men; 110,991 women) and the UK Biobank (52,188 men;…

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Educational disparities in the association of protein diversity and type 2 diabetes: a multi-country population-based prospective case-cohort study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Purpose To investigate socio-economic disparities in the association between dietary diversity and type 2 diabetes (T2D). Methods Prospective secondary analysis study of 10,363 incident cases of T2D over 12 years and a random sub-cohort of 13,937 individuals in the EPIC-InterAct case-cohort study. We used baseline self-reported diet data (1991–1998) to construct scores for diversity between food…

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Polygenic scores for risk of pancreatic ductal adenocarcinoma: evaluation of novel and published models

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Polygenic risk scores (PRSs) may enhance risk stratification for pancreatic ductal adenocarcinoma (PDAC), but existing models vary widely in design, predictive performance, and cross-ancestry transferability. We developed genome-wide PRSs using Bayesian methods (LDpred2 and PRS-CS) and p value thresholding (PRSice-2) and systematically evaluated these alongside 13 published PRSs to identify models with robust predictive performance…

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A prospective study of physical activity and cardiometabolic diseases in association with cancer risk

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Most physical activity research focuses on general populations, and its cancer-preventive benefits in adults with cardiometabolic diseases remain poorly understood. This study investigated associations between non-occupational physical activity and cancer risk in adults with and without cardiometabolic diseases (cardiovascular disease and/or type 2 diabetes). Methods We conducted a meta-analysis of individual participant data of…

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Sociodemographic and residential characteristics associated to persistent and non-persistent organic pollutants in household dust from Southern Spain. COVID-AND Study

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Background Scientific evidence suggests that indoor dust contains chemical pollutants, such as per- and polyfluoroalkyl substances (PFAS), bisphenols, parabens, and benzophenones, which are present in building materials and everyday products and could have implications for human health. Objective To quantify levels of PFAS, bisphenols, parabens, and benzophenones in household dust of four cohorts from Andalusia…

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Meat Intake and Risk of Gastric and Esophageal Adenocarcinoma in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Whether meat consumption increases the risk of gastric cancer (GC) and esophageal cancer or not remains unclear. Moreover, the number of prospective studies evaluating the associations by anatomical and histological types of GC is limited. We aimed to assess the associations of red, processed, and white meat with all gastric adenocarcinomas by anatomical site and…

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Linking Nutri-Score dietary profiles to metabolic biomarkers in a cross-sectional study within the multinational EPIC cohort

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

The front-of-pack label Nutri-Score has been implemented in several European countries since 2017 to guide consumers towards foods of higher nutritional value. A few studies reported associations between Nutri-Score dietary profiles reflecting a lower nutritional quality, however not using the 2023-updated version of the algorithm, and profiles of biomarkers consistent with increased metabolic risk. Our…

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Assessing the role of ultra-processed foods in colorectal cancer incidence: insights from the EPIC cohort

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Studies have reported associations between ultra-processed food (UPF) consumption and colorectal cancer (CRC) incidence, yet the magnitude of these associations remains unclear. This study estimated the cohort-associated fraction (CAF), adapted from the population-attributable fraction metric, between UPF consumption and CRC incidence and explored the potential benefits of substituting UPFs with unprocessed or minimally processed…

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Premenopausal and postmenopausal obesity and endometrial cancer risk: circulating biomarkers of inflammation, insulin resistance, and sex hormones as mediators

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Obesity may increase endometrial cancer risk through pathways involving chronic inflammation, insulin resistance, and altered sex hormone levels. Methods Within the European Prospective Investigation into Cancer and Nutrition cohort, we investigated these mediating pathways using prediagnostic circulating biomarkers measured in 337 matched case-control pairs with postmenopausal measurements and 196 pairs with premenopausal measurements. We…