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Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. Methods: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and…

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Follow-up care of 12 months of patients with bladder cancer in Spain: A multicenter prospective cohort study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

The therapeutic approach of bladder cancer strongly determines its prognosis. We describe the treatments and outcomes for a Spanish cohort of patients with bladder cancer for the first 12 months after diagnosis and identify the factors that influenced the decision to undergo the treatment received. We conducted a multicenter, prospective, cohort study including primary bladder…

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Food Processing and Risk of Crohn’s Disease and Ulcerative Colitis: A European Prospective Cohort Study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background & Aims Industrial foods have been associated with increased risks of several chronic conditions. We investigated the relationship between the degree of food processing and risks of Crohn’s disease (CD) and ulcerative colitis (UC) in the European Prospective Investigation into Cancer and Nutrition cohort. Methods Analyses included 413,590 participants (68.6% women; mean baseline age,…

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Cardiorespiratory Fitness and Bone Turnover Markers in Adults With Metabolic Syndrome: The Mediator Role of Inflammation

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

The relationship between inflammatory markers and bone turnover in adults is well known, and a negative association between cardiorespiratory fitness (CRF) and inflammatory markers has also been described. Hence, we tested whether the association between CRF and bone turnover markers is mediated by inflammatory markers in adults with metabolic syndrome. A total of 81 adults…

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The patient, diagnostic, and treatment intervals in adult patients with cancer from high- and lower-income countries: A systematic review and meta-analysis

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Longer time intervals to diagnosis and treatment are associated with worse survival for various types of cancer. The patient, diagnostic, and treatment intervals are considered core indicators for early diagnosis and treatment. This review estimated the median duration of these intervals for various types of cancer and compared it across high- and lower-income countries.…

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La historia se repite: una ética para dos pandemias

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

La irrupción del virus de la inmunodeficiencia humana (VIH) en la década de los 80 trajo consigo conflictos éticos que supusieron un desafío para la Bioética. Surgieron, entre otros, problemas de confidencialidad, estigmatización, justicia, deber de asistencia y de investigación. Si hasta entonces la reflexión bioética había estado centrada en los conflictos protagonizados por el…

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Bias in algorithms of AI systems developed for COVID-19: A scoping review

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

To analyze which ethically relevant biases have been identified by academic literature in artificial intelligence (AI) algorithms developed either for patient risk prediction and triage, or for contact tracing to deal with the COVID-19 pandemic. Additionally, to specifically investigate whether the role of social determinants of health (SDOH) have been considered in these AI developments…

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Development of the European Healthcare and Social Cost Database (EU HCSCD) for use in economic evaluation of healthcare programs

Artículos Científicos, Igualdad, Investigación

Introduction Costs are one of the critical factors for the transferability of the results in health technology assessment and economic evaluation. The objective is to develop a cost database at the European level to facilitate cross-border cost comparisons in different settings and explains the factors that lead to differences in healthcare costs in different countries,…

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Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

To identify bioaccumulation patterns of α-, β- hexachlorocyclohexane (HCH) and dicofol in relation to sociodemographic, dietary, and lifestyle factors, adipose tissue samples of 387 subjects from GraMo cohort in Southern Spain were analyzed. Potential predictors of these organochlorine pesticides (OCP) levels were collected by face-to-face interviews and assessed by multivariable linear and logistic regression. OCPs…

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Predictive Model and Mortality Risk Score during Admission for Ischaemic Stroke with Conservative Treatment

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Background: Stroke is the second cause of mortality worldwide and the first in women. The aim of this study is to develop a predictive model to estimate the risk of mortality in the admission of patients who have not received reperfusion treatment. Methods: A retrospective cohort study was conducted of a clinical–administrative database, reflecting all…