Flame retardants (FRs) are chemicals used to reduce the flammability of materials and are commonly found in consumer products such as furniture and electronics. These substances can migrate from products (e.g., furniture foam and electronic devices) into indoor environments such as air and dust and may pose risk to human health by direct exposure. Some…
The aim of this study was to investigate associations between human exposure to persistent organic pollutants and sex hormone levels. The study population (n = 253) was a subsample of GraMo adult cohort, recruited in 2003–2004 in two hospitals from Granada, Spain. Exposure was estimated by analyzing samples of adipose tissue (3 organochlorine pesticides and…
Background Adiposity, measured by body mass index (BMI), is a known risk factor for postmenopausal breast cancer. However, whether the association of BMI with breast cancer risk differs among women with and without cardiovascular diseases (CVDs) or type 2 diabetes (T2D) is uncertain. Methods This study used individual participant data from the European Prospective Investigation…
Dado el crecimiento exponencial de la producción científica, resulta imprescindible que profesionales y la comunidad universitaria dispongan de herramientas y competencias para hacer eficiente la búsqueda de información relevante. Las necesidades de información requieren ser trabajadas y transformadas en preguntas susceptibles de ser contestadas, para lo que resulta de gran utilidad la adaptación al formato…
Objetivo: Sintetizar la evidencia disponible sobre la reducción gradual de la dosis de antipsicóticos o su deprescripción abrupta en personas mayores con demencia. Métodos: Revisión sistemática de estudios de intervención. Se consultaron las bases de datos PubMed, Embase, Web of Science-Core Collection, Cochrane Library, Scopus, MEDLINE (Ovid) y PsycINFO. Se incluyeron estudios (ensayos aleatorios o…
Background Despite being generally considered healthy, adolescence is a crucial period where health behaviours are established, which can impact future well-being. Factors such as social determinants, psychosocial variables, and risk behaviours play significant roles in determining general and mental health, with important gender differences. This article aims to study social inequalities in the prevalence of…
Background/Objectives: We examined the association between dietary intake and blood concentrations of one-carbon metabolism (OCM)-related nutrients in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Blood concentrations and dietary intake of the vitamins riboflavin (B2), Pyridoxal 5′-phosphate (PLP and B6), folate (B9), B12, and methionine, concentrations of homocysteine, and dietary intake of betaine,…
Abstract Objective To estimate the risk of developing a second primary cancer (SPC) among women diagnosed with breast cancer in Granada, Spain. Study design This population-based observational cohort study utilized data from the Granada Cancer Registry. We included all women aged 15 and above diagnosed with malignant breast cancer from 1985 to 2019. Main outcome…
Background Immunocompromised patients present a higher risk of severe influenza disease and respond worse to vaccination. Objective We aimed to assess immunogenicity and safety of high-dose vs. standard-dose influenza vaccine in immunocompromised patients. Data source A search was conducted in Medline, Web of Science, Scopus and ClinicalTrials.gov from inception to March 2024 with no other…
Background Colon cancer is strongly influenced by lifestyle factors. Sociodemographic factors like sex and socioeconomic position (SEP) might modulate the relationship between lifestyle and colon cancer risk. Metabolomics offers potential to uncover biological mechanisms linking lifestyle and colon cancer. Methods Lifestyle and untargeted metabolomic data were available from a nested case–control study within the European…
