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Association Between Dietary Intake and Blood Concentrations of One-Carbon-Metabolism-Related Nutrients in European Prospective Investigation into Cancer and Nutrition

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background/Objectives: We examined the association between dietary intake and blood concentrations of one-carbon metabolism (OCM)-related nutrients in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Blood concentrations and dietary intake of the vitamins riboflavin (B2), Pyridoxal 5′-phosphate (PLP and B6), folate (B9), B12, and methionine, concentrations of homocysteine, and dietary intake of betaine,…

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Risk of a second primary cancer after breast cancer in Southern Spain: a population-based study over 3 decades

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Abstract Objective To estimate the risk of developing a second primary cancer (SPC) among women diagnosed with breast cancer in Granada, Spain. Study design This population-based observational cohort study utilized data from the Granada Cancer Registry. We included all women aged 15 and above diagnosed with malignant breast cancer from 1985 to 2019. Main outcome…

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Can serum metabolic signatures inform on the relationship between healthy lifestyle and colon cancer risk?

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Colon cancer is strongly influenced by lifestyle factors. Sociodemographic factors like sex and socioeconomic position (SEP) might modulate the relationship between lifestyle and colon cancer risk. Metabolomics offers potential to uncover biological mechanisms linking lifestyle and colon cancer. Methods Lifestyle and untargeted metabolomic data were available from a nested case–control study within the European…

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Revisión sistemática sobre el uso de peces para el control vectorial de las enfermedades transmitidas por mosquitos

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

FUNDAMENTOS // Se estima que un 80% de la población mundial está en riesgo de contraer una enfermedad de transmisión vectorial, siendo los mosquitos los responsables de una mayor carga de enfermedad. Dado que el control biológico es una opción más natural que otras intervenciones disponibles y que el uso de peces está muy extendido,…

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Metabolic profile of biodiverse diets in a healthy European cohort

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background There is increasing evidence that diets characterized by food biodiversity could contribute to health outcomes. Greater dietary species diversity has been linked to reduced gastrointestinal cancer risk and all-cause mortality. However, mechanistic pathways supporting the association between food biodiversity and health are just beginning to be explored. Aim To characterize the metabolic profile associated…

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Nut consumption, linoleic and α-linolenic acid intakes, and genetics: how fatty acid desaturase 1 impacts plasma fatty acids and type 2 diabetes risk in EPIC-InterAct and PREDIMED studies

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Background Dietary guidelines recommend replacing saturated fatty acid with unsaturated fats, particularly polyunsaturated fatty acids. Cohort studies do not suggest a clear benefit of higher intake of polyunsaturated fatty acids but, in contrast, higher circulating linoleic acid (LA) levels—reflective of dietary LA intake, are associated with a reduced risk of type 2 diabetes. However, genetic…

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Relationship Between Health-Related Behaviors and Family Quality of Life in Children with Autism Spectrum Disorder

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Improving family quality of life (FQoL) of families of children with autism spectrum disorder (ASD) is a key priority in clinical research and practice. Previous studies have suggested that certain health-related behaviors in children with ASD, such as sleep or physical activity, may affect FQoL. However, the relative and independent effects of different health-related behaviors…

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Trends in the incidence of brain cancer and the use of mobile phones: analysis of the Spanish Network of Cancer Registries (REDECAN)

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Purpose The association between the use of mobile phones use and the risk of brain cancer remains controversial. The aim of this study is to describe trends in the incidence of central nervous system (CNS) cancers in Spain and its possible relationship with mobile phone use. Methods Trends and trend changes from 1985 to 2015…

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Cohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses)

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

The CORDELIA Study (Collaborative Cohorts Reassembled Data to Study Mechanisms and Long-term Incidence of Chronic Diseases) combines 35 Spanish population cohorts to investigate the clinical, environmental, genetic, and omics determinants of cardiovascular disease in the Southern European population. It aims to conduct the largest genome-wide association study to date on cardiovascular disease in this population,…

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Identification and prioritisation of biomarkers of organophosphorus compounds-induced neurotoxicity

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Organophosphorus compounds (OPCs), a diverse group of chemicals widely utilised as pesticides and flame retardants, pose significant neurotoxic risks, even during neurodevelopment. While their primary molecular and cellular targets are well characterised, growing evidence suggest additional mechanisms, particularly in developmental neurotoxicity. Despite extensive research, predictive biomarkers of OPC-induced neurotoxicity beyond acetylcholinesterase remain underexplored. This study…