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Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Micro- and nanoplastics (MNPs) are increasingly recognized as emerging contaminants of concern for human health. Their small size, diverse composition, and reactive surface enable interactions with biological barriers and cellular systems. This comprehensive narrative review synthesizes and critically evaluates current evidence on the mechanistic effects of MNPs in humans and experimental models. Systemic mechanisms, including…

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Nutrient adequacy and environmental foot-print of Mediterranean, pesco-, ovo-lacto-, and vegan menus: a modelling study

Artículos Científicos, Cáncer, Investigación

Background: Consumer food choices are changing towards a more plant-based diet (PBD) due to growing awareness of their less detrimental effects on health and the environment. However, PBDs—particularly vegan diets—may lead to nutritional deficiencies compared to non-PBDs. These differences may, in part, be influenced by the typically lower caloric content of PBDs. Objective: To compare…

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What cancers are increasing in young adults: a population-based study of incidence trends in adults 20–49 years old in the South of Spain

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Recent studies have documented sharp increases in the incidence of several types of cancer in young adults, highlighting the need to monitor and understand epidemiological trends in this population. The aim of this study was to analyze cancer incidence trends among young adults (20–49 years) in the province of Granada, Spain, from 1985 to…

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Synergies between food biodiversity, processing levels, and the Eat-Lancet diet for nutrient adequacy and environmental sustainability: a multi-objective optimization using the EPIC cohort

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Diets have become increasingly monotonous and high in ultra-processed foods (UPFs), contributing to poor health outcomes and environmental degradation. While sustainable diets, food biodiversity, and food processing levels have each been linked to nutritional and environmental outcomes, their combined impact has not been assessed. Objective To examine whether food biodiversity, intakes of UPFs, and…

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Overcoming barriers to off-patent drug repurposing: a lifecycle-based policy solutions

Artículos Científicos, Investigación

Introduction: Drug repurposing leverages existing medicines to reduce time and costs for exploring new therapeutic indications. However, off-patent medicines do not provide enough private incentives for investment, and prescribing by active ingredient can be a major barrier. Academics and non-profit sponsors also face regulatory barriers. Methods: This study combined a structured literature review with a…

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Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background The associations between different types of diabetes, characterized by distinct pathophysiology and genetic architecture, and pancreatic ductal adenocarcinoma (PDAC) risk are not understood. Methods We investigated associations of genetic susceptibility to type 2 diabetes (T2D), 8 T2D mechanistic clusters, type 1 diabetes (T1D), and maturity-onset diabetes of the young (MODY) with PDAC risk. We…

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Cost-Effectiveness of Sacituzumab Govitecan and Physician’s Choice of Treatment in Patients with Metastatic Triple Negative Breast Cancer in Spain

Artículos Científicos, Investigación

Background and Objectives Patients with metastatic triple-negative breast cancer (mTNBC) have poor prognosis and survival outcomes. Sacituzumab govitecan (SG) has shown significant survival benefits, but its cost-effectiveness still needs evaluation. The present study aimed to evaluate the cost-effectiveness of SG versus physician’s choice of treatment in patients with mTNBC in the context of the Spanish…

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Evaluation of the 4Kscore Test in Relation to Subsequent Risk of Aggressive Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background: PSA is central to referrals for prostate biopsy but has low specificity for aggressive prostate cancer. This study evaluates the 4Kscore (OPKO Diagnostics) versus total PSA in predicting short- and long-term risks of aggressive prostate cancer. Methods: Baseline blood samples from 1,658 men diagnosed with prostate cancer (median diagnosis time = 8.6 years) and…

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Skin melanoma survival is improving in Europe but regional differences persist: Results of the EUROCARE-6 study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background The aim of this study was to update previous EUROCARE survival estimates for skin melanoma (SM) monitoring trends and survival differences between European regions. Methods 1-year, 5-year, and 5-year/1-year conditional age-standardised relative survival (ASRS) and geographical comparisons were estimated on 280,498 patients participating in the EUROCARE-6 project (>=15 years old) with invasive SM (diagnosed…

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Lifestyle changes and postmenopausal breast cancer risk in women from the European Prospective Investigation into Cancer and Nutrition

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background The risk of breast cancer has been associated with various lifestyle factors, yet the evidence regarding how lifestyle modifications affect this risk remains limited. This study examines the relationship between changes in the Healthy Lifestyle Index (HLI) and postmenopausal breast cancer risk in women participating in the European Prospective Investigation into Cancer (EPIC). Methods…