Transferable Exclusivity Extension Vouchers for Antimicrobials: Incentive Design, Implementation Challenges, and Policy Trade-Offs

Antimicrobial resistance (AMR) is one of the greatest threats to public health, and forecasts for 2050 are even worse. In response, the European Commission (EC) is proposing the Transferable Exclusivity Extension Voucher (TEEV), which aims to encourage the development of innovative antimicrobials. It consists of extending data exclusivity for a medicine selected by the beneficiary…

The 3V score and joint associations of low ultra-processed food, biodiverse and plant-based diets on colorectal cancer risk: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Background Diet may modify colorectal cancer risk. We investigated the associations of three dietary patterns, ultra-processed food (UPF) consumption, healthy plant-based food consumption, and food biodiversity, separately and combined into a “3V” score with risk of colorectal cancer. Methods This study used data from the prospective European Prospective Investigation into Cancer and Nutrition (EPIC) cohort,…

Cost-effectiveness of second- or third-line treatment with tisotumab vedotin for metastatic or recurrent cervical cancer

Objective To evaluate the cost-effectiveness of tisotumab vedotin (TV) versus single-agent chemotherapy in recurrent or metastatic cervical cancer (r/mCC) after failure of first-line treatment, from the perspective of the Spanish National Health System. Methods Cost-utility analysis was conducted using a partitioned survival model with three health states, over a 60-month time horizon. Efficacy data ‒overall…

Personalized prevention of neurodegenerative diseases: scoping review and evidence gap map

Neurodegenerative diseases represent a major public health challenge due to their high prevalence and poor prognosis. Identifying biomarkers to stratify individuals by their risk of developing these diseases may help to define new personalized prevention interventions. The objective of this study was to conduct a scoping review of biomarkers for primary and secondary personalized prevention…

The euthanasia law from the perspective of healthcare professionals in Spain

Background In 2021, Spain passed Organic Law 3/2021, which regulates euthanasia and represents an extension of rights to make decisions in the context of health care. According to the Law, the state must guarantee access to Medical Assistance in Dying (MAiD) through health services. Therefore, the involvement of health professionals is crucial. The aim of…

The relationship between psychological stress and cancer incidence: a systematic review and meta-analysis

This systematic review of prospective studies examined whether psychological stress—conceptualised as cumulative stressful life events or perceived stress—is associated with cancer incidence. It was pre-registered in PROSPERO (IDCRD42020175681) and conducted following PRISMA guidelines. Methodological quality was assessed using the NIH Tool for Observational Studies, and the certainty of evidence was assessed using the GRADE tool.…

Cost-Utility Analysis of Left Bundle Branch Area Versus Biventricular Pacing for Cardiac Resynchronization Therapy: A Multicenter, Prospective, Quasi-Experimental Study

Introduction Cardiac resynchronization therapy (CRT) is a well-established treatment for patients with heart failure (HF). Recently, left bundle branch area pacing (LBBAP) has emerged as a more physiological alternative to biventricular pacing (BVP) for CRT. This study aimed to evaluate the cost-utility of LBBAP CRT compared with BVP CRT. Methods A cost-utility, non-randomized, prospective, multicenter,…

Acción Comunitaria para ganar Salud

Guía Acción Comunitaria para ganar Salud…o cómo trabajar en común para mejorar las condiciones de vida Descargar Guía (edición 2025) Coordinación institucional: Ministerio de Sanidad. Dirección General de Salud Pública. Subdirección General de Promoción, Prevención y Calidad Coordinación técnica: Mariano Hernán García. Escuela Andaluza de Salud Pública Jara Cubillo Llanes. Ministerio de Sanidad ¿A quién…

Alimentación Saludable

DESCARGAR PUBLICACIÓNWEB DE RELAS La alimentación y los problemas relacionados con ella (como la obesidad o las enfermedades crónicas) tienen un gran impacto en la salud y calidad de vida de las personas y en los sistemas de salud. La alimentación saludable sigue siendo uno de los pilares fundamentales de la promoción de la salud.…

Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects

Micro- and nanoplastics (MNPs) are increasingly recognized as emerging contaminants of concern for human health. Their small size, diverse composition, and reactive surface enable interactions with biological barriers and cellular systems. This comprehensive narrative review synthesizes and critically evaluates current evidence on the mechanistic effects of MNPs in humans and experimental models. Systemic mechanisms, including…