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Adipose tissue concentrations of arsenic, nickel, lead, tin, and titanium in adults from GraMo cohort in Southern Spain: An exploratory study

Artículos Científicos

Background Adipose tissue has been acknowledged as a potential target for obesogenic pollutants, including toxic metal(loid)s. However, the presence of these chemicals in the adipose tissue has been poorly characterized. Objective To examine the distributions of adipose tissue concentrations of five toxic metal(loid)s (i.e., arsenic [As], nickel [Ni], lead [Pb], tin [Sn], and titanium [Ti])…

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Genome-Wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

Artículos Científicos

Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes…

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Desigualdades de género en la autoría de las principales revistas médicas españolas durante el año 2017

Artículos Científicos

Introducción El objetivo del estudio es analizar la desigualdad de género en la producción científica de las revistas médicas españolas. Material y método Estudio transversal de las principales revistas médicas españolas clasificadas por SCImago Journal & Country Ranking (n=24) y sus publicaciones (n=3.375) durante el año 2017. Se calculó la ratio mujer/hombre de autoría según…

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The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries

Artículos Científicos

Aim To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. Methods and results We analysed data on 418 329 men and women from nine European countries, with an average of 12.7 years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over…

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Psychosocial markers of pre‐hospital decision delay and psychological distress in acute coronary syndrome patients

Artículos Científicos

Objectives Both pre‐hospital decision delay – the time patients wait before seeking medical attention after symptoms have started – and high psychological distress after the cardiac episode predict poor prognosis of patients with acute coronary syndromes (ACS). We aimed to identify psychosocial markers of these prognostic factors. Design A cross‐sectional study of 102 consecutive, clinically…

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Effect of the Financial Crisis on Socioeconomic Inequalities in Mortality in Small Areas in Seven Spanish Cities

Artículos Científicos

Background: The aim of this study was to analyze the trend in socioeconomic inequalities in mortality in small areas due to several specific causes before (2001–2004, 2005–2008) and during (2009–2012) the economic crisis in seven Spanish cities. Methods: This ecological study of trends, with census tracts as the areas of analysis, was based on three…

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Budget Impact Analysis of Dalbavancin in the Treatment of Acute Bacterial Skin and Skin Structure Infections in Three European Countries

Artículos Científicos

Background and Objective Acute bacterial skin and skin structure infections (ABSSSIs) have been defined by the US Food and Drug Administration (FDA) in 2013 to include a subset of complicated skin and skin structure infections commonly treated with parenteral antibiotic therapy. Inpatient treatment of ABSSSIs involves a significant economic burden on the healthcare system. This…

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Does the use of health technology assessment have an impact on the utilisation of health care resources? Evidence from two European countries

Artículos Científicos

Objectives A centralised approach to health technology assessment (HTA) may facilitate optimal use of HTA resources. A regional approach may increase the chances of local implementation of recommendations. This study aimed to compare assessment procedures in England (centralised HTA approach) with Spain (regional HTA approach) discussing key challenges and opportunities from both approaches. Methods We…

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Serum levels of hsa‐miR‐16‐5p, ‐29a‐3p, ‐150‐5p, ‐155‐5p and ‐223‐3p and subsequent risk of chronic lymphocytic leukemia in the EPIC study

Artículos Científicos

Chronic lymphocytic leukemia (CLL) is an incurable disease accounting for almost one‐third of leukemias in the Western world. Aberrant expression of microRNAs (miRNAs) is a well‐established characteristic of CLL, and the robust nature of miRNAs makes them eminently suitable liquid biopsy biomarkers. Using a nested case‐control study within the European Prospective Investigation into Cancer and…

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Theoretical potential for endometrial cancer prevention through primary risk factor modification: Estimates from the EPIC cohort

Artículos Científicos

Endometrial cancer (EC) incidence rates vary ~10‐fold worldwide, in part due to variation in EC risk factor profiles. Using an EC risk model previously developed in the European EPIC cohort, we evaluated the prevention potential of modified EC risk factor patterns and whether differences in EC incidence between a European population and low‐risk countries can…