Global variation in patterns of care and time to initial treatment for breast, cervical, and ovarian cancer from 2015 to 2018 (VENUSCANCER): a secondary analysis of individual records for 275 792 women from 103 population-based cancer registries in 39 countries and territories

Background Cancers of the breast, cervix, and ovary are a major public health problem worldwide. Evaluating the consistency with clinical guidelines for treatment by use of individual high-resolution data from population-based cancer registries is a powerful tool to help interpretation of global inequalities in cancer survival. The VENUSCANCER project aims to assess the worldwide variation…

Understanding and reframing clinical errors through just culture: protocol for the DECIDE mixed-methods study in Spanish healthcare and community contexts

Introduction Patient safety culture plays a crucial role in reducing clinical errors. By improving healthcare professionals’ and patients’ understanding of human fallibility and error attribution, patient care can be enhanced, fostering greater engagement from both groups. A Just Culture approach, which balances accountability and learning from errors, is a key factor in fostering this safety…

Gender inequalities of caregiver mental health and burden in the three years post COVID-19 (CUIDAR-SE Study)

Background The COVID-19 pandemic has significantly impacted progress towards the Sustainable Development Goals (SDGs), particularly SDG 3 (ensuring healthy lives and well-being) and SDG 5 (achieving gender equality), especially for caregivers. Increased demand for informal caregiving has disproportionately impacted caregivers, worsening mental health challenges. Intense burden reinforces traditional gender norms and exacerbates health inequities, linking…

Biomarkers for Personalised Primary or Secondary Prevention in Cardiovascular Diseases: A Rapid Scoping Review

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality globally. Early detection and personalised prevention strategies are crucial for reducing the burden of CVD. The use of biomarkers plays a pivotal role in identifying individuals at risk and facilitating timely interventions. This rapid scoping review aims to identify and evaluate current research on…

Factors influencing the diagnostic basis in pancreatic cancer. A study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Background and aims Substantial differences have been reported in risk estimates for etiologic factors of pancreatic cancer among subjects with different degrees of diagnostic certainty. The aim of the study was to assess the influence of some personal and social characteristics on the diagnostic basis in individuals with pancreatic cancer. Methods We analyzed 393 participants…

Intake of total, classes, and subclasses of (poly)phenols and risk of lymphoid neoplasms: a prospective analysis in the EPIC cohort

Background Existing epidemiological evidence regarding the potential role of (poly)phenol intake in lymphoma development is limited. Methods We investigated the associations between the intake of total and individual classes and subclasses of (poly)phenols and the risk of lymphoma, including main frequent subtypes in the EPIC cohort using multivariable-adjusted Cox proportional hazards models. Results During a…

Encuestas Poblacionales de Salud en España: descripción de metodologías y contenidos

FUNDAMENTOS // Las Encuestas Poblacionales de Salud (EPS) son herramientas clave para evaluar el estado de salud de la población y sus determinantes. Desde 1977, la Organización Mundial de la Salud (OMS) impulsó su desarrollo en distintos países para mejorar la planificación y evaluación de las políticas sanitarias. El objetivo de este trabajo fue identificar…

Survival trends and cure rates of hematological neoplasms in the Spanish pediatric population

Hematological neoplasms (HN) were the first cause of death in children aged 5–9 years in Spain. The aim of this registry-based study is to provide a detailed overview of the survival of HN in the Spanish pediatric population. All pediatric HN cases included were classified according to the International Classification for Childhood Cancer. Flexible parametric…

Walkability, Right to the City and Right to Health: pathways toward equity and justice – a systematic mixed-methods review

This paper explores the intersection of walkability, the Right to Health and the Right to the City, with a particular emphasis on equitable access in rapidly urbanizing environments. Urbanization exacerbates challenges to health inequities, particularly for vulnerable populations with limited access to walkable, health-promoting spaces. Through a systematic mixed-methods literature review, we analyze how walkability…

Transcriptomic profiling unveils novel therapeutic options for drug-resistant temporal lobe epilepsy

Background Epilepsy drug treatments fail in 25–30 % of patients, leading to drug resistance. Temporal lobe epilepsy is the most prevalent subtype associated with drug resistance. Classical drug discovery is a long and extremely costly process with a high failure rate in clinical trials. Drug repurposing is a more cost- and time-effective strategy. Hence, the main…