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Comparative clinical outcomes of acenocoumarol versus direct oral anticoagulants (DOACs) and warfarin in patients with atrial fibrillation: real-world-evidence (SIESTA-A study)

Artículos Científicos

Objective: The aim of this study was to evaluate the effectiveness and safety of direct oral anticoagulants (DOACs: dabigatran, rivaroxaban, apixaban and edoxaban) and warfarin versus acenocoumarol in patients with atrial fibrillation under real-world clinical practice conditions. Methods: This was a retrospective, real-world data-based study. The data source was the Andalusian Population Health Database. The…

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Gestational exposure to organophosphate pesticides and maternal urine metabolomic profile in the GENEIDA birth cohort

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Early developmental exposure to organophosphate (OP) pesticides has been linked to adverse health effects, though the underlying molecular pathways remain unclear. This study examined urinary metabolomic profiles of 387 pregnant women in their first and third trimesters using UPLC-MS/MS to identify metabolic disruptions associated with OPs exposure measured via dialkyl phosphate (DAPs) metabolites, including total,…

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Thyroid hormones and epithelial ovarian cancer risk and survival: results from the European Prospective Investigation into Cancer and Nutrition study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Thyroid-stimulating hormone (TSH) and thyroid hormones (free triiodothyronine [fT3] and free thyroxine [fT4]) may influence cancer outcomes, but evidence for ovarian cancer is limited. Methods We conducted a nested case–control study comparing 578 epithelial ovarian cancer (EOC) cases with matched controls within the European Prospective Investigation into Cancer and Nutrition (EPIC). To examine associations…

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Young Men’s Communication Needs for the Human Papillomavirus (HPV) Vaccine: A Cross-Cultural, Qualitative Analysis in Scotland, Spain, and the USA

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Globally, human papillomavirus (HPV) vaccine uptake rates have declined within a wider context of vaccine hesitancy. Gender-neutral vaccine programmes are increasing and recommended for the prevention of cervical, anogenital, and oropharyngeal cancers affecting both women and men. To address the problem of suboptimal HPV uptake rates for boys and men, we aimed to understand…

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A Framework for Considering the Role of the Public Sector in R&D of Health Technology

Artículos Científicos

The development of health technologies involves complex, costly, and risky investments, with significant contributions from both public and private sectors. Recent EU pharmaceutical directives propose transparency on public funding to aid pricing negotiations and affordability. However, questions remain regarding how public investments should be measured and their influence on pricing and reimbursement (P&R) decisions. In…

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Economic Evaluation of Treatment With Trastuzumab Deruxtecan for HER2-Low Advanced or Metastatic Breast Cancer in Previously Treated Patients

Artículos Científicos

Objectives This study evaluates the efficiency and budgetary impact of trastuzumab deruxtecan (T-DXd) compared with standard therapy in previously treated HER2-low advanced or metastatic breast cancer, from the perspective of the Spanish National Health System. Methods A partitioned survival model was developed using data from the DESTINY-BREAST04 trial. Health outcomes were measured in quality-adjusted life…

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Perceived acceptability of sexual violence against women in Spain and associated factors

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Sexual violence (SV) is considered a major public health problem affecting the lifelong health, opportunities, and wellbeing of hundreds of millions of people.1 Most recent estimates from the World Health Organization (WHO) indicate that 27 % of females aged over 15 experience physical and/or SV at the hands of their partner, whilst 6 % suffer SV from…

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Estimated exposure of flame-retardants in Spanish toddlers: a modelling approach

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Flame retardants (FRs) are chemicals used to reduce the flammability of materials and are commonly found in consumer products such as furniture and electronics. These substances can migrate from products (e.g., furniture foam and electronic devices) into indoor environments such as air and dust and may pose risk to human health by direct exposure. Some…

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Ética y Salud Pública

Publicaciones EASP

Este texto forma parte de los resultados de investigación de la red ESPACyOS. Ética de la Salud Pública, financiada por la Agencia Estatal de Investigación (RED2022- 134551-T) y con la  colaboración de FECYT-Ministerio de Ciencia, Innovación y Universidades (FCT-24-19978) y POyETICAS (PID2023-148517NB-100). Primera edición, 2025 © Maite Cruz, Joaquín Hortal y Àngel Puyol, 2025 ©…

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Associations of internal persistent organic pollutant levels with sex hormones: An analysis by sex and menopausal status in a Spanish cohort

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

The aim of this study was to investigate associations between human exposure to persistent organic pollutants and sex hormone levels. The study population (n = 253) was a subsample of GraMo adult cohort, recruited in 2003–2004 in two hospitals from Granada, Spain. Exposure was estimated by analyzing samples of adipose tissue (3 organochlorine pesticides and…