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Alteration of Amino Acid and Biogenic Amine Metabolism in Hepatobiliary Cancers: Findings from a Prospective Cohort Study

Artículos Científicos

Perturbations in levels of amino acids (AA) and their derivatives are observed in hepatocellular carcinoma (HCC). Yet, it is unclear whether these alterations precede or are a consequence of the disease, nor whether they pertain to anatomically related cancers of the intrahepatic bile duct (IHBC), and gallbladder and extrahepatic biliary tract (GBTC). Circulating standard AA,…

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Clinical intervals and diagnostic characteristics in a cohort of prostate cancer patients in Spain: a multicentre observational study

Artículos Científicos

Background: Little is known about the healthcare process for patients with prostate cancer, mainly because hospital-based data are not routinely published. The main objective of this study was to determine the clinical characteristics of prostate cancer patients, the, diagnostic process and the factors that might influence intervals from consultation to diagnosis and from diagnosis to treatment.…

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Prolactin Determinants in Healthy Women: A Large Cross-Sectional Study within the EPIC Cohort

Artículos Científicos

Background: Experimental and epidemiologic data suggest that higher circulating prolactin is associated with breast cancer risk; however, how various risk factors for breast cancer influence prolactin levels in healthy women is not clear. Methods: We analyzed cross-sectional associations between several suggested reproductive and lifestyle risk factors for breast cancer and circulating prolactin among pre- and…

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Effectiveness of the cold chain control procedure in the retail sector in Southern Spain

Artículos Científicos

The official procedure adopted in Andalusia (Southern Spain) for implementing the hazard analysis and critical control points (HACCP) flexibility criteria for the control of the cold chain in the retail self-service sector set out in Regulation (CE) 852/2004 is based on a daily determination of the display temperature of the equipment. The main objective of…

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Cuestiones controvertidas en evaluación económica (II): medidas de resultado en salud de las intervenciones sanitarias

Artículos Científicos

En este segundo artículo, de una serie de tres, debatiremos, empleando la técnica Metaplan, sobre cuestiones controvertidas de las medidas de resultado en salud en la evaluación económica de intervenciones sanitarias (EEIS). Las cuatro áreas de debate se centraron en: elección de las medidas de resultado en salud: en abstracto ninguna medida es superior a…

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El valor afectivo de los fragmentos del cuerpo: dimensiones culturales de la ‪donación de órganos‬ en la España democrática

Artículos Científicos

In this paper we analyze the emotionality linked to the medical technology of organ transplants during the 1980s in Spain. Using the newspapers ABC, El Pais, and other visual materials, we explore the individual feelings expressed in the media by donors and receptors. More importantly, we expose the «emotionology» that emphasized solidarity as a source…

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Energy and macronutrient intake and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Artículos Científicos

Incidence rates of differentiated thyroid carcinoma (TC) have increased in many countries. Adiposity and dietary risk factors may play a role, but little is known on the influence of energy intake and macronutrient composition. The aim of this study is to investigate associations between TC and the intake of energy, macronutrients, glycemic index (GI) and…

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Human Papillomavirus Antibodies and Future Risk of Anogenital Cancer: A Nested Case-Control Study in the European Prospective Investigation Into Cancer and Nutrition Study

Artículos Científicos

Purpose: Human papillomavirus (HPV) type 16 (HPV16) causes cancer at several anatomic sites. In the European Prospective Investigation Into Cancer and Nutrition study, HPV16 E6 seropositivity was present more than 10 years before oropharyngeal cancer diagnosis and was nearly absent in controls. The current study sought to evaluate the extent to which HPV16 E6 antibodies…