LupaDetalles

Premenopausal and postmenopausal obesity and endometrial cancer risk: circulating biomarkers of inflammation, insulin resistance, and sex hormones as mediators

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Obesity may increase endometrial cancer risk through pathways involving chronic inflammation, insulin resistance, and altered sex hormone levels. Methods Within the European Prospective Investigation into Cancer and Nutrition cohort, we investigated these mediating pathways using prediagnostic circulating biomarkers measured in 337 matched case-control pairs with postmenopausal measurements and 196 pairs with premenopausal measurements. We…

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Intake of the Total, Classes, and Subclasses of (Poly)phenols and Breast Cancer Risk: A Prospective Analysis of the EPIC Study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Polyphenols represent the largest and most diverse class of dietary antioxidants. Epidemiological evidence linking specific (poly)phenol classes, such as flavonoids and lignans, to breast cancer (BC) risk remains limited and largely inconclusive in prospective studies. The aim of this study is to examine the association between the intake of total (poly)phenols—and its classes and subclasses—and…

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Associations between dietary exposure to dioxins and polychlorinated biphenyls (PCBs) and Longitudinal changes in weight and waist circumference– an EPIC study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background: Obesity is a growing global health concern. Some evidence suggests that exposure to polychlorinated biphenyls (PCBs) and dioxins, may play a role in weight gain, but human prospective data are limited and have shown inconsistent results. Therefore, this study investigate the association between dietary exposure to dioxins and PCBs and changes in weight and…

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Nuevas formas de reticencia a la vacunación en la era pos-COVID-19: un estudio cualitativo

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Objetivo Analizar los argumentos para dudar o rechazar cualquiera de las vacunas contra la COVID-19 y cómo estos discursos han podido modificarse tras la experiencia de la pandemia. Método Se desarrolló un estudio cualitativo exploratorio-descriptivo durante 2021-2022, con cuatro entrevistas semiestructuradas y tres grupos focales mediante muestreo teórico a personas reticentes a las vacunas contra…

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Higher intake of dietary dicarbonyl compounds is associated with lower incidence of type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study

Artículos Científicos, Cáncer

Purpose Dicarbonyls are reactive precursors of advanced glycation end-products. They are formed during food processing, and endogenously in humans during glycolysis and lipid peroxidation. Higher plasma dicarbonyls, particularly methylglyoxal (MGO), promote insulin resistance and type 2 diabetes, but the association between dietary dicarbonyls intake and type 2 diabetes is unknown. This study examined the associations…

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Proteomics signature of moderate-to-vigorous physical activity and risk of multimorbidity of cancer and cardiometabolic diseases

Artículos Científicos, Cáncer, Igualdad, Mujeres EASP

Background Moderate-to-vigorous physical activity (MVPA) is inversely associated with risks of cancer, cardiovascular diseases (CVD), type 2 diabetes (T2D), and their co-occurrence, defined as multimorbidity; however, the underlying biological pathways remain unclear. Methods In 33,806 UK Biobank participants with 2911 measured blood proteins, a proteomic signature of MVPA was derived with linear and LASSO regressions.…

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The complex price setting and reimbursement of non-industrial advanced therapy medicinal products

Artículos Científicos

Background Advanced Therapy Medicinal Products (ATMPs) developed under the Hospital Exemption (HE) offer innovative treatments for patients with unmet medical needs, but their pricing and reimbursement (P&R) remain fragmented and poorly understood. This paper examines the P&R landscape for HE-ATMPs developed by academic developers in Spain, based on the Spanish costing guideline and extends the…

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Factores contextuales y uso de heurísticos en atención por intensivistas a pacientes críticos durante la pandemia COVID-19: estudio cuasi-experimental con viñetas en Chile

Artículos Científicos

Introducción La decisión clínica en unidades de cuidados intensivos en pandemia por COVID-19 ha sido escasamente estudiada. Los objetivos del estudio son determinar la variabilidad de las decisiones de intensivistas en Chile, analizar la asociación de la decisión clínica con ciertos factores contextuales (hora, ola pandémica, edad del paciente, información clínica disponible) y estimar la…

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A proteomics approach to identify predictive blood biomarkers for pleural mesothelioma in prospective cohorts

Artículos Científicos, Cáncer

Background Pleural mesothelioma (PM) is a rare, asbestos-linked cancer with a long asymptomatic latency, delaying diagnosis and limiting treatment options. Identifying blood‐based biomarkers that signal disease before symptoms onset could improve surveillance of at‐risk individuals. Methods In our work, we conducted a prospective proteomic study of pre-diagnostic serum from 21 PM cases (< 5 years before…

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Policy approach to optimize multiple myeloma treatment sequencing practices

Artículos Científicos

Introduction As a consequence of major therapeutic advances that have transformed multiple myeloma (MM) into a manageable chronic condition, treatment sequencing has become highly complex. According to current practices, novel therapies are predominantly reserved for later disease stages, yet limited evidence suggests that this approach yields optimal long-term outcomes. Understanding the drivers of current practices…