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Dietary and lifestyle determinants of acrylamide and glycidamide hemoglobin adducts in non-smoking postmenopausal women from the EPIC cohort

Artículos Científicos

Purpose Acrylamide was classified as ‘probably carcinogenic’ to humans in 1994 by the International Agency for Research on Cancer. In 2002, public health concern increased when acrylamide was identified in starchy, plant-based foods, processed at high temperatures. The purpose of this study was to identify which food groups and lifestyle variables were determinants of hemoglobin…

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Anticoncepción de urgencia y objeción de conciencia: un debate sin cerrar

Artículos Científicos

El objetivo de este editorial es reflexionar sobre la anticoncepción de urgencia y las posibles implicaciones para la salud pública de la reciente Sentencia del Tribunal Constitucional (STC) sobre el recurso de amparo interpuesto por el cotitular de una oficina de farmacia por supuesta vulneración del derecho a la objeción de conciencia al haber sido…

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Experiencias, modelos y claves para la coordinación e integración de servicios sociales y sanitarios

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El desarrollo de la coordinación de servicios sociales y sanitarios se fundamenta en un modelo universal, orientado a facilitar la realización del proyecto vital de cada persona, contando con su entorno más próximo1. Este modelo determina que el sujeto y protagonista de la acción es la persona y su entorno de convivencia, y que esta…

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Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort

Artículos Científicos

Background: Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer development. These processes may contribute to leakage of bacterial products, such as lipopolysaccharide (LPS) and flagellin, across the gut barrier. The objective of this study, nested within a prospective cohort, was to examine associations between circulating LPS and flagellin serum antibody…

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Prospective association of liver function biomarkers with development of hepatobiliary cancers

Artículos Científicos

Introduction Serum liver biomarkers (gamma-glutamyl transferase, GGT; alanine aminotransferase, ALT; aspartate aminotransferase, AST; alkaline phosphatase, ALP; total bilirubin) are used as indicators of liver disease, but there is currently little data on their prospective association with risk of hepatobiliary cancers. Methods A nested-case control study was conducted within the prospective EPIC cohort (>520,000 participants, 10…

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The Use of Statistics in Health Sciences: Situation Analysis and Perspective

Artículos Científicos

Statistics plays a crucial role in research, planning and decision-making in the health sciences. Progress in technologies and continued research in computational statistics has enabled us to implement sophisticated mathematical models within software that are handled by non-statistician researchers. As a result, over the last decades, medical journals have published a host of papers that…

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Elaboración de criterios e indicadores para desarrollar y evaluar programas de envejecimiento saludable en los lugares de trabajo

Artículos Científicos

Fundamentos: En el actual contexto poblacional de envejecimiento de la población y prolongación de la vida laboral, los programas de promoción de salud en el trabajo son una herramienta clave y necesaria para promover un envejecimiento activo y saludable. El objetivo fue elaborar una herramienta tipo lista de verificación para orientar la planificación, implementación y…

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Modeling the costs and long-term health benefits of screening the general population for risks of cardiovascular disease: a review of methods used in the literature

Artículos Científicos

Background Strategies for screening and intervening to reduce the risk of cardiovascular disease (CVD) in primary care settings need to be assessed in terms of both their costs and long-term health effects. We undertook a literature review to investigate the methodologies used. Methods In a framework of developing a new health-economic model for evaluating different…

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Subtypes of fruit and vegetables, variety in consumption and risk of colon and rectal cancer in the European Prospective Investigation into Cancer and Nutrition

Artículos Científicos

Previously, a lower risk of colorectal cancer was observed with fruit and vegetable consumption in the European Prospective Investigation into Cancer and Nutrition within a follow-up period of 9 years which was not fully supported by a recent meta-analysis. Therefore, we were interested in the relation with extended follow-up, also focusing on single subtypes and…

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The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition

Background: Higher coffee intake has been purportedly related to a lower risk of liver cancer. However, it remains unclear whether this association may be accounted for by specific biological mechanisms. Objective: We aimed to evaluate the potential mediating roles of inflammatory, metabolic, liver injury, and iron metabolism biomarkers on the association between coffee intake and…