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Determination of oleanolic acid in human plasma and its association with olive oil intake in healthy Spanish adults within the EPIC Spain cohort study

Artículos Científicos

Scope Oleanolic acid (OA) is an important triterpenic compound found in olive oil, however little is known about its concentrations in human plasma. We aimed to determine plasma OA levels in a healthy Spanish population and compare them with estimates of dietary olive oil intake. Methods and results The final study sample included 141 individuals…

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Barriers and enablers in the implementation of a program to reduce cesarean deliveries

Artículos Científicos

Background Conducting audits, implementing best practices and giving feedback to the professionals have shown considerable promise in reducing rates of cesarean delivery and mother-child morbidity. The purpose of the study is two-fold: a) to identify the factors that facilitate change in current practices and thus reduce the use of obstetric interventions, and b) to better…

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Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study

Artículos Científicos

Background:The relationship between coffee consumption and mortality in diverse European populations with variable coffee preparation methods is unclear. Objective:To examine whether coffee consumption is associated with all-cause and cause-specific mortality. Design:Prospective cohort study. Setting:10 European countries. Participants:521 330 persons enrolled in EPIC (European Prospective Investigation into Cancer and Nutrition). Measurements:Hazard ratios (HRs) and 95% CIs estimated…

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Health assessments for health governance: concepts and methodologies

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Background: For better supporting the science-governance interface, the potential of health assessments appears underrated. Aims: To identify what various types of health assessment have in common; how they differ; which assessment(s) to apply for which purpose; and what needs and options there are for future joint development. Methods: This review is based on five types…

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Hospital admissions due to alcohol related disorders among young adult refugees who arrived in Sweden as teenagers – a national cohort study

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Background Psychological distress and lack of family support may explain the mental health problems that are consistently found in young unaccompanied refugees in Western countries. Given the strong relationship between poor mental health and alcohol misuse, this study investigated hospital admissions due to alcohol related disorders among accompanied and unaccompanied young refugees who settled in…

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Tendencia de la obesidad infantil y el bajo peso por año de nacimiento y edad en España, 1983-2011

Artículos Científicos

Introducción y objetivos Las prevalencias de obesidad infantil y sobrepeso están en aumento en todo el mundo y representan un importante problema de salud pública, especialmente en los perfiles de riesgo cardiovascular en la edad adulta si la obesidad no se revierte. La identificación precisa de las tendencias y los subgrupos en riesgo es crucial…

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Health-related quality of life in Spanish informal caregivers: gender differences and support received

Artículos Científicos

Purpose We analyzed gender differences in health-related quality of life (HRQoL) and associated factors between informal male and female caregivers in Spain. It is important because of growing rates of dependent people and dwindling public resources. Methods We conducted a cross-sectional study of 610 informal caregivers (265 male and 345 female) using an ad hoc…

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Unlocking the potential of established products: toward new incentives rewarding innovation in Europe

Artículos Científicos

Background: Many established products (EPs – marketed for eight years or more) are widely used off-label despite little evidence on benefit–risk ratio. This exposes patients to risks related to safety and lack of efficacy, and healthcare providers to liability. Introducing new indications for EPs may represent a high societal value; however, manufacturers rarely invest in R&D…

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Evaluación de las prescripciones fuera de ficha técnica: perfil, evidencia y evolución

Artículos Científicos

Objetivo: Los objetivos del estudio fueron describir la magnitud y el perfil de las prescripciones fuera de ficha técnica (off-label), evaluar el nivel de evidencia en el que se sustentan estas indicaciones, valorar la actividad investigadora en estas enfermedades y determinar en qué grado se autorizan como nuevas indicaciones transcurridos cinco años desde la solicitud. Métodos: Estudio transversal que incluyó…