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Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

Artículos Científicos

Background Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. Methods We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income…

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Risk Prediction for Renal Cell Carcinoma: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Prospective Cohort Study

Artículos Científicos

Background: Early detection of renal cell carcinoma (RCC) has the potential to improve disease outcomes. No screening program for sporadic RCC is in place. Given relatively low incidence, screening would need to focus on people at high risk of clinically meaningful disease so as to limit overdiagnosis and screen-detected false positives. Methods: Among 192,172 participants…

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Risk prediction for estrogen receptor-specific breast cancers in two large prospective cohorts

Artículos Científicos

Background Few published breast cancer (BC) risk prediction models consider the heterogeneity of predictor variables between estrogen-receptor positive (ER+) and negative (ER-) tumors. Using data from two large cohorts, we examined whether modeling this heterogeneity could improve prediction. Methods We built two models, for ER+ (ModelER+) and ER- tumors (ModelER-), respectively, in 281,330 women (51%…

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Risk perception, attitudes, and quality of life in a multicomponent benzodiazepine deprescription strategy

Artículos Científicos, Investigación

Background Multicomponent strategies can reduce benzodiazepine (BZD) use. BenzoStopJuntos (Spanish for “Stop Benzos Together”), a multidisciplinary deprescribing programme of the Andalusian Health Service, supports patients to taper/stop BZD through education, behavioral support, and non-pharmacological alternatives. We evaluated whether early changes (6 months) in risk perception and attitudes—and secondarily, quality of life—were associated with long-term discontinuation of…

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Risk of suicide in households threatened with eviction: the role of banks and social support

Artículos Científicos

Background One of the greatest effects of the financial crisis in Spain has been the enormous increase in the number of evictions. Several studies have shown the association of evictions with different aspects of the physical and mental health. Furthermore, evictions have been associated with an increased risk of suicide. Our objective was to evaluate…

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Risk of a second primary cancer after breast cancer in Southern Spain: a population-based study over 3 decades

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Abstract Objective To estimate the risk of developing a second primary cancer (SPC) among women diagnosed with breast cancer in Granada, Spain. Study design This population-based observational cohort study utilized data from the Granada Cancer Registry. We included all women aged 15 and above diagnosed with malignant breast cancer from 1985 to 2019. Main outcome…

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Revisión sistemática sobre el uso de peces para el control vectorial de las enfermedades transmitidas por mosquitos

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

FUNDAMENTOS // Se estima que un 80% de la población mundial está en riesgo de contraer una enfermedad de transmisión vectorial, siendo los mosquitos los responsables de una mayor carga de enfermedad. Dado que el control biológico es una opción más natural que otras intervenciones disponibles y que el uso de peces está muy extendido,…

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Review and Assessment of Policy Options for Improving Access to Combination Therapies in Oncology in Europe

Artículos Científicos

Objectives Combinations of on-patent therapies (CTs) are increasingly common in oncology. They cause challenges for funding and affordability, and hence patient access, especially when constituent therapies are owned by different manufacturers. The aim of our study was to develop policy proposals for the assessment, pricing, and funding of CTs and identify which might be relevant…

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Retraso en el acceso al primer tratamiento para la adicción en usuarios de opiáceos

Artículos Científicos, Investigación

La búsqueda temprana de tratamiento para la adicción a los opiáceos se relaciona con un aumento de las posibilidades de éxito en el mismo. Los nuevos pacientes que buscan este tratamiento, y el tiempo que tardan en demandarlo, han sido escasamente descritos en España y Europa. El objetivo del presente estudio es identificar los factores…