LupaDetalles

Trends in cutaneous malignant melanoma incidence, mortality and survival over three decades: a population-based study in Southern Spain

Cáncer, Igualdad, Investigación, Mujeres EASP

Background Cutaneous malignant melanoma (CMM) represents a global public health problem. Epidemiological studies about CMM trends tend to focus on single indicators or lack information about tumour characteristics that can help gain a more thorough understanding of CMM epidemiology. Objectives To fill this gap, we studied CMM trends in incidence, mortality and survival over three…

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Reformas de atención primaria en América Latina: avances en Brasil, Chile, Colombia, México y Perú

En América Latina, desde los años 1990 se iniciaron reformas estructurales, con diferente grado de éxito. Uno de sus objetivos primordiales ha sido transformar los sistemas de salud, con énfasis en fortalecer la atención primaria de salud (APS), promoviendo un enfoque integral y cohesivo, reduciendo la fragmentación en la prestación de servicios, mejorando la coordinación…

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Gut Microbial Metabolites and Future Risk of Parkinson’s Disease: A Metabolome-Wide Association Study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Alterations in gut microbiota are observed in Parkinson’s disease (PD). Previous studies on microbiota-derived metabolites in PD were small-scale and post-diagnosis, raising concerns about reverse causality. Objectives Our goal was to prospectively investigate the association between plasma microbial metabolites and PD risk within a metabolomics framework. Methods A nested case–control study within the prospective…

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Communicating Probabilities of Cervical Cancer Screening Results with Icon Arrays or Tree Diagrams: A Longitudinal Experiment

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Simple graphical displays such as icon arrays and tree diagrams have been proposed for communicating health risks and supporting informed decisions. The UK’s National Health Service (NHS) uses tree diagrams to communicate the chances of different cervical cancer screening results, but their effectiveness has not been compared to icon arrays. We conducted a well-powered longitudinal…

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Sex- and site-specific associations of circulating lipocalin 2 and incident colorectal cancer: Results from the EPIC cohort

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Experimental research has uncovered lipocalin 2 (LCN2) as a novel biomarker implicated in the modulation of intestinal inflammation, metabolic homeostasis, and colon carcinogenesis. However, evidence from human research has been scant. We, therefore, explored the association of pre-diagnostic circulating LCN2 concentrations with incident colorectal cancer (CRC) in a nested case–control study within the in the…

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Micronutrients, Vitamin D, and Inflammatory Biomarkers in COVID-19: A Systematic Review and Meta-analysis of Causal Inference Studies

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Context Experimental and observational studies suggest that circulating micronutrients, including vitamin D (VD), may increase COVID-19 risk and its associated outcomes. Mendelian randomization (MR) studies provide valuable insight into the causal relationship between an exposure and disease outcomes. Objectives The aim was to conduct a systematic review and meta-analysis of causal inference studies that apply MR…

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Degree of food processing and breast cancer risk: a prospective study in 9 European countries

Recent epidemiological studies have suggested a positive association between ultra-processed food consumption and breast cancer risk, although some studies also reported no association. Furthermore, the evidence regarding the associations between intake of food with lower degrees of processing and breast cancer risk is limited. Thus, we investigated the associations between dietary intake by degree of…

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International Prevalence of Technology-Facilitated Sexual Violence Against Women: A Systematic Review and Meta-Analysis of Observational Studies

Igualdad, Investigación, Mujeres EASP

The aim of the present review was to systematically identify and examine current knowledge regarding the frequency of any form of technology-facilitated sexual violence (TFSV) perpetrated against women aged 16 years and older. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist was applied when performing the present review. Observational studies reporting prevalence data for…

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Perturbations in the blood metabolome up to a decade before prostate cancer diagnosis in 4387 matched case–control sets from the European Prospective Investigation into Cancer and Nutrition

Cáncer, Igualdad, Investigación, Mujeres EASP

Measuring pre-diagnostic blood metabolites may help identify novel risk factors for prostate cancer. Using data from 4387 matched case–control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, we investigated the associations of 148 individual metabolites and three previously defined metabolite patterns with prostate cancer risk. Metabolites were measured by liquid chromatography-mass…

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Association of circulating fatty acids with cardiovascular disease risk: Analysis of individual-level data in three large prospective cohorts and updated meta-analysis

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Associations of saturated and unsaturated fatty acids (FAs) with cardiovascular disease (CVD) remain controversial. We therefore aimed to investigate the prospective associations of objectively measured FAs with CVD, including incident coronary heart disease (CHD) and stroke, as well as CVD mortality. Methods Circulating FA concentrations expressed as the percentage of total FAs were assayed…