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Circulating Isovalerylcarnitine and Lung Cancer Risk: Evidence from Mendelian Randomization and Pre-Diagnostic Blood Measurements

Artículos Científicos

Background: Tobacco exposure causes 8 of 10 lung cancers, and identifying additional risk factors is challenging due to confounding introduced by smoking in traditional observational studies. Materials and Methods: We used Mendelian randomization (MR) to screen 207 metabolites for their role in lung cancer predisposition using independent genome-wide-association studies (GWAS) of blood metabolite levels (n…

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Brecha de género persistente en la parada cardiaca extrahospitalaria en España durante el periodo 2013-2018

Artículos Científicos

Objetivos. Examinar las diferencias de género en las características de la parada cardiaca extrahospitalaria (PCRE), los tratamientos, la supervivencia, y los cambios evolutivos en España. Método. Datos de dos series temporales (2013/2014 y 2017/2018) del registro prospectivo de PCRE (OHSCAR). Se incluyeron todos los casos consecutivos en los que intervino un equipo de emergencias. Las…

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Diet-wide association study of 92 foods and nutrients and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition study and the Netherlands Cohort Study

Artículos Científicos, Cáncer, Investigación

It is unclear whether diet, and in particular certain foods or nutrients, are associated with lung cancer risk. We assessed associations of 92 dietary factors with lung cancer risk in 327,790 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC). Cox regression yielded adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) per…

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Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Background: Obesity is a risk factor for endometrial cancer but whether metabolic dysfunction is associated with endometrial cancer independent of body size is not known. Methods: The association of metabolically defined body size phenotypes with endometrial cancer risk was investigated in a nested case–control study (817 cases/ 817 controls) within the European Prospective Investigation into…

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Prevalence and Clinical Conditions Related to Sarcopaenia among Older Persons Living in the Community

Artículos Científicos

Background: In health care and in society at large, sarcopaenia is a disorder of major importance that can lead to disability and other negative health-related events. Our study aim is to determine the prevalence of sarcopaenia among older people attended in primary care and to analyse the factors associated with this age-related clinical condition; (2)…

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Sustained Negative Mental Health Outcomes Among Healthcare Workers Over the First Year of the COVID-19 Pandemic: A Prospective Cohort Study

Artículos Científicos

Objective: To characterize the evolution of healthcare workers’ mental health status over the 1-year period following the initial COVID-19 pandemic outbreak and to examine baseline characteristics associated with resolution or persistence of mental health problems over time. Methods: We conducted an 8-month follow-up cohort study. Eligible participants were healthcare workers working in Spain. Baseline data…

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¿Permiso para investigar? Reflexiones sobre los requisitos éticos de la observación participante en el contexto de la entrevista familiar de obtención de órganos

Artículos Científicos, Investigación, Mujeres EASP

Aunque se han identificado muchos de los factores que pueden influir en la donación, el momento de la entrevista en la que se les solicita a las familias su autorización para la extracción de órganos parece ser decisivo. Sin embargo, son escasos los estudios que analizan este proceso cuando dicha entrevista tiene lugar. Técnicas cualitativas…

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Participación comunitaria: aprendizajes de la COVID-19 para nuevas crisis. Informe SESPAS 2022

Artículos Científicos

La gestión de la pandemia de COVID-19ha dejado en segundo plano la participación comunitaria, a pesar de la evidencia de su importancia para la equidad y la promoción de la salud. Aun así, ha habido experiencias participativas que aportan claves de cara a cómo enfrentar posibles emergencias futuras incorporando un enfoque de promoción de la…

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Frequency, Types, and Manifestations of Partner Sexual Violence, Non-Partner Sexual Violence and Sexual Harassment: A Population Study in Spain

Artículos Científicos, Investigación, Mujeres EASP

Background: This study analyzes the frequency and sociodemographic characteristics associated with sexual violence by a partner/ex-partner (PSV), someone other than a partner or ex-partner (NPSV), or sexual harassment (SH). Methods: The study is based on the 2019 Macro-survey of Violence against Women conducted by the Spanish Ministry of Equality among a sample of 9568 women…

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Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition

Artículos Científicos, Cáncer

Background & aims Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed. Methods Circulating ACs were measured in blood…