Prospective analysis of circulating metabolites and endometrial cancer risk

Background Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective Investigation into Cancer…

Geographical Variability in Mortality in Urban Areas: A Joint Analysis of 16 Causes of Death

The geographical distribution of mortality has frequently been studied. Nevertheless, those studies often consider isolated causes of death. In this work, we aim to study the geographical distribution of mortality in urban areas, in particular, in 26 Spanish cities. We perform an overall study of 16 causes of death, considering that their geographical patterns could…

Development and evaluation of a training programme on asset-based community development aimed at general practice trainees: protocol for a mixed-method multilevel and multicentric action research study

Introduction Asset-based community development (ABCD) is a strategy aimed at strengthening communities of interest through the identification and enhancement of those protective resources (also called ‘health assets’) that contribute to improve population health. Although primary care is specially well placed to contribute to ABCD by facilitating patients’ access to community health assets, the implementation of…

Concentrations of bisphenol-A in adults from the general population: A systematic review and meta-analysis

Background Human bisphenol-A (BPA) exposure has been linked to adverse health effects even at low doses, which may be of potential public health concern. Objective To summarize BPA concentrations in general human population and their variability according to sex, geographic area, and analytical method. Methods Systematic review and meta-analysis of studies reporting BPA concentrations in…

Los vídeos como herramienta de difusión científica y transferencia de conocimiento

La investigación científica no puede dar la espalda a los nuevos hábitos de consumo de la información. En este nuevo escenario donde está disminuyendo de manera generalizada la capacidad de atención, las nuevas generaciones utilizan cada vez con más frecuencia el vídeo como herramienta clave para el acceso al conocimiento. En este sentido, parece oportuno,…

Novel Biomarkers of Habitual Alcohol Intake and Associations with Risk of Pancreatic and Liver Cancers and Liver Disease Mortality

Background Alcohol is an established risk factor for several cancers, but modest alcohol-cancer associations may be missed due to measurement error in self-reported assessments. Biomarkers of habitual alcohol intake may provide novel insight into the relationship between alcohol and cancer risk. Methods Untargeted metabolomics was used to identify metabolites correlated with self-reported habitual alcohol intake…

Barriers and Benefits of the Scheduled Telephone Referral Model (DETELPROG): A Qualitative Approach

The recently developed scheduled mobile-telephone referral model (DETELPROG) has achieved especially important results in reducing waiting days for patients, but it has been decided to explore what barriers and positive aspects were detected by both primary care physicians (PCPs) and hospital attending physicians (HAPs) regarding its use. For this, a qualitative descriptive study was carried…

Associations of accumulated selected persistent organic pollutants in adipose tissue with insulin sensitivity and risk of incident type-2 diabetes

Continuous exposure to low doses of persistent organic pollutant (POPs), such as those occurring in the general population, might contribute to the burden of type 2 diabetes mellitus (T2DM). However, evidences from longitudinal studies are scarce. We aimed to explore the associations of accumulated POP exposure with the development of T2DM by means of 1)…

Comprehension and Recall of Information about Factors Associated to Peri‐Implantitis: A Randomized Controlled Trial

Aim : To evaluate the effect of different communication strategies on comprehension and recall of information about factors associated to peri‐implantitis. Material and methods : A prospective, randomized controlled trial was conducted in consecutive patients diagnosed with peri‐implantitis. The sample was divided into three groups according to the communication strategy used: Test group1 – Written communication…