LupaDetalles

Polymorphisms in VDR, CYP27B1, CYP2R1, GC and CYP24A1 Genes as Biomarkers of Survival in Non-Small Cell Lung Cancer: A Systematic Review

Artículos Científicos, Cáncer, Investigación

The objective of this systematic review was to provide a compilation of all the literature available on the association between single-nucleotide polymorphisms (SNPs) in the genes involved in the metabolic pathway of vitamin D and overall survival (OS) and progression-free survival (PFS) in patients with non-small cell lung cancer (NSCLC). This systematic review was conducted…

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The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study

Artículos Científicos, Cáncer

Evidence linking body fatness to breast cancer (BC) prognosis is limited. While it seems that excess adiposity is associated with poorer BC survival, there is uncertainty over whether weight changes reduce mortality. This study aimed to assess the association between body fatness and weight changes pre- and postdiagnosis and overall mortality and BC-specific mortality among…

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Allostatic Load and Depression Symptoms in Cancer Survivors A National Health and Nutrition Examination Survey Study

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Background Individuals with cancer often experience stress throughout the cancer trajectory and have a high risk of experiencing depression. Objective The aim of this study was to examine the relationship between allostatic load (AL), a measure of cumulative stress-related physiologic dysregulation of different body systems, and symptoms of depression in cancer survivors. Methods Participants were…

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Review and Assessment of Policy Options for Improving Access to Combination Therapies in Oncology in Europe

Artículos Científicos

Objectives Combinations of on-patent therapies (CTs) are increasingly common in oncology. They cause challenges for funding and affordability, and hence patient access, especially when constituent therapies are owned by different manufacturers. The aim of our study was to develop policy proposals for the assessment, pricing, and funding of CTs and identify which might be relevant…

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Food processing and cancer risk in Europe: results from the prospective EPIC cohort study

Artículos Científicos, Cáncer

Background Food processing has been hypothesised to play a role in cancer development; however, data from large-scale epidemiological studies are scarce. This study investigated the association between dietary intake according to amount of food processing and risk of cancer at 25 anatomical sites using data from the European Prospective Investigation into Cancer and Nutrition (EPIC)…

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Cancer awareness in older adults: Results from the Spanish Onco-barometer cross-sectional survey

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Background About half of all cancers are diagnosed in adults older than 65, making them the age group at highest risk of developing this disease. Nurses from different specialties can support individuals and communities in the prevention and early detection of cancer and should be aware of the common knowledge gaps and perceived barriers among older adults. Objectives The…

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Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts

Cáncer, Igualdad, Investigación, Mujeres EASP

Background Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank…

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Relationship between Sexual Violence and the Health of Spanish Women—A National Population-Based Study

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Background: Health consequences are likely to be different when sexual violence is analysed independently from other types of violence. It is also likely that different health consequences will result in the cases of partner or ex-partner sexual violence, non-partner sexual violence and sexual harassment. Methods: This study is based on the 2019 Macro-survey of Violence…

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Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk. Objectives To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies. Methods Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95%…

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The social value of a PASI 90 or PASI 100 response in patients with moderate-to-severe plaque psoriasis in Spain

Artículos Científicos

Introduction: Psoriasis is a chronic disease involving the skin, which significantly impacts the quality of life. Disease severity and treatment efficacy (i.e., response) are assessed through the Psoriasis Area and Severity Index (PASI). A PASI 75 response, i.e., an improvement of at least 75% with respect to the baseline PASI score, has traditionally been used as…