LupaDetalles

International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

PURPOSE There is strong evidence that leisure-time physical activity is protective against postmenopausal breast cancer risk but the association with premenopausal breast cancer is less clear. The purpose of this study was to examine the association of physical activity with the risk of developing premenopausal breast cancer. METHODS We pooled individual-level data on self-reported leisure-time…

LupaDetalles

Breast cancer risk for the joint exposure to metals and metalloids in women: Results from the EPIC-Spain cohort

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Environmental factors play a role in breast cancer development. While metals and metalloids (MMs) include some carcinogens, their association with breast cancer depends on the element studied. Most studies focus on individual MMs, but the combined effects of metal mixtures remain unclear. The aim of this study was to analyze the relationship between the joint…

LupaDetalles

Centenary Personality: Are There Psychological Resources that Distinguish Centenarians?

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

The number of centenarians is increasing year by year. Considering that happier people are likely to live longer, we asked ourselves whether healthy centenarians share psychological resources or positive personality characteristics that have enabled them to face traumatic situations and the challenges life more successfully. To our knowledge this is an issue that has not…

LupaDetalles

Pricing and reimbursement mechanisms for advanced therapy medicinal products in 20 countries

Artículos Científicos

Introduction: Advanced Therapy Medicinal Products are a type of therapies that, in some cases, hold great potential for patients without an effective current therapeutic approach but they also present multiple challenges to payers. While there are many theoretical papers on pricing and reimbursement (P&R) options, original empirical research is very scarce. This paper aims to…

Detalles

External Validation and Recalibration of a Mortality Prediction Model for Patients with Ischaemic Stroke

Artículos Científicos, Cáncer, Investigación

Background: Stroke is a highly prevalent disease that can provoke severe disability. We evaluate a predictive model based on the Minimum Basic Data Set (MBDS) compiled by the Spain Health Ministry, obtained for the period 2008–2012 for patients with ischaemic stroke in Spain, to establish the model’s validity and to optimise its calibration. The MBDS…

LupaDetalles

Body mass index and cancer risk among adults with and without cardiometabolic diseases: evidence from the EPIC and UK Biobank prospective cohort studies

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Background Whether cancer risk associated with a higher body mass index (BMI), a surrogate measure of adiposity, differs among adults with and without cardiovascular diseases (CVD) and/or type 2 diabetes (T2D) is unclear. The primary aim of this study was to evaluate separate and joint associations of BMI and CVD/T2D with the risk of cancer.…

LupaDetalles

Dietary intakes of dioxins and polychlorobiphenyls (PCBs) and mortality: EPIC cohort study in 9 European countries

Artículos Científicos, Investigación

Dioxins and polychlorinated biphenyls (PCBs) are toxic, endocrine disruptors and persistent chemicals for which the main exposure source is diet due to their bioaccumulation and biomagnification in food chains. Cohort studies in the general populations have reported inconsistent associations between these chemicals in serum/plasma and mortality. Our objective was to study the association between dietary…

LupaDetalles

Ultra-processed foods, adiposity and risk of head and neck cancer and oesophageal adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition study: a mediation analysis

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Purpose To investigate the role of adiposity in the associations between ultra-processed food (UPF) consumption and head and neck cancer (HNC) and oesophageal adenocarcinoma (OAC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods Our study included 450,111 EPIC participants. We used Cox regressions to investigate the associations between the consumption of…

LupaDetalles

The impact of COVID-19 pandemic on out-of-hospital cardiac arrest: an individual patient data meta-analysis

Artículos Científicos, Investigación

Aim Prior studies have reported increased out-of-hospital cardiac arrests (OHCA) incidence and lower survival during the COVID-19 pandemic. We evaluated how the COVID-19 pandemic affected OHCA incidence, bystander CPR rate and patients’ outcomes, accounting for regional COVID-19 incidence and OHCA characteristics. Methods individual patient data meta-analysis of studies which provided a comparison of OHCA incidence…

LupaDetalles

Comparative effects of different types of exercise on health-related quality of life during and after active cancer treatment: A systematic review and network meta-analysis

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Background The positive influence of most types of exercise has been reported repeatedly, but what the most effective exercise approaches are for improving health-related quality of life (HRQoL) in people with cancer remains unknown. The aim of this systematic review and network meta-analysis was to synthesize the evidence from intervention studies to assess the effects…