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Age at Menopause and the Risk of Stroke: Observational and Mendelian Randomization Analysis in 204 244 Postmenopausal Women

Artículos Científicos, Cáncer, Investigación

Background Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear. Methods and Results We analyzed data of the UK Biobank and EPIC‐CVD (European Prospective Investigation Into Cancer and Nutrition‐Cardiovascular…

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Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Background We sought to develop a proteomics-based risk model for lung cancer and evaluate its risk-discriminatory performance in comparison with a smoking-based risk model (PLCOm2012) and a commercially available autoantibody biomarker test. Methods We designed a case-control study nested in 6 prospective cohorts, including 624 lung cancer participants who donated blood samples at most 3 years…

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Prediagnostic Blood Metal Levels and the Risk of Parkinson’s Disease: A Large European Prospective Cohort

Artículos Científicos, Cáncer, Investigación

Background Metals have been postulated as environmental concerns in the etiology of Parkinson’s disease (PD), but metal levels are typically measured after diagnosis, which might be subject to reverse causality. Objective The aim of this study was to investigate the association between prediagnostic blood metal levels and PD risk. Methods A case-control study was nested…

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Single Nucleotide Polymorphisms in the Vitamin D Metabolic Pathway as Survival Biomarkers in Colorectal Cancer

Artículos Científicos, Cáncer, Investigación

Several studies have suggested that single nucleotide polymorphisms (SNPs) related to vitamin D metabolism may affect CRC carcinogenesis and survival. The aim of this study was to evaluate the influence of 13 SNPs involved in the vitamin D metabolic pathway on CRC survival. We conducted an observational retrospective cohort study, which included 127 Caucasian CRC…

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Intake of the Total, Classes, and Subclasses of (Poly)Phenols and Risk of Prostate Cancer: A Prospective Analysis of the EPIC Study

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Existing epidemiological evidence regarding the potential role of (poly)phenol intake in prostate cancer (PCa) risk is scarce and, in the case of flavonoids, it has been suggested that their intake may increase PCa risk. We investigated the associations between the intake of the total and individual classes and subclasses of (poly)phenols and the risk of…

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The duration of intervals on the oral cancer care pathway and implications for survival: a systematic review and meta-analysis

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Introduction: Previous studies measuring intervals on the oral cancer care pathway have been heterogenous, showing mixed results with regard to patient outcomes. The aims of this research were (1) to calculate pooled meta-analytic estimates for the duration of the patient, diagnostic and treatment intervals in oral cancer, considering the income level of the country, and…

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Incidence and time trends of childhood hematological neoplasms: a 36-year population-based study in the southern European context, 1983–2018

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Background: Hematological neoplasms (HNs) are the first and most common childhood cancers globally. Currently, there is a lack of updated population-based data on the incidence of these cancers in the Spanish pediatric population. This study aimed to describe the incidence and incidence trends of HNs in children (0–14 years) in Spain using data from the…

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Scoping review of the methodology of large health surveys conducted in Spain early on in the COVID-19 pandemic

Artículos Científicos, Investigación, Mujeres EASP

Background: The use of health surveys has been key in the scientific community to promptly communicate results about the health impact of COVID-19. But what information was collected, where, when and how, and who was the study population? Objective: To describe the methodological characteristics used in large health surveys conducted in Spain early on in…

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Clinical Outcomes of First-line Therapies for Advanced Non–Small Cell Lung Cancer A Systematic Review of Trials Published Between 2010 and 2020

Artículos Científicos, Investigación

Objectives: To analyze the evolution of clinical outcomes derived from clinical trials on first-line therapies for advanced or metastatic non–small cell lung cancer (NSCLC) published between 2010 and 2020, focusing on how these outcomes impact survival rates and management of patients. Methods: A systematic review of phase III and pivotal phase II clinical trials was…

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INES: Interactive tool for construction and extrapolation of partitioned survival models

Artículos Científicos, Investigación

Background INES (INteractive model for Extrapolation of Survival and cost) provides an open-access tool powered by R that implements three-state partitioned survival models (PSM). This article describes the properties of the tool, and the situations where INES may or may not be suitable. Methods INES is designed to be used by investigators or healthcare professionals…