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Cohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses)

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

The CORDELIA Study (Collaborative Cohorts Reassembled Data to Study Mechanisms and Long-term Incidence of Chronic Diseases) combines 35 Spanish population cohorts to investigate the clinical, environmental, genetic, and omics determinants of cardiovascular disease in the Southern European population. It aims to conduct the largest genome-wide association study to date on cardiovascular disease in this population,…

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Nutritional profile of the diet according to circadian clock genes in the European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet study

Artículos Científicos, Cáncer, Igualdad

Background & aims Circadian rhythms seem to impact both dietary intake and metabolism, depending on the individual’s chronotype. We aimed to explore whether the nutritional composition of meals throughout the day is influenced by genetics linked to the circadian clock and chronotype within the “European Prospective Investigation into Cancer and Nutrition (EPIC) chronodiet” study. Methods…

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Monitoring of the oncological process for lung cancer in Spain: an expert consensus report

Artículos Científicos

Introduction Continuous monitoring of the oncological process is essential for identifying inefficiencies and areas of improvement, enabling better resource allocation in the care of lung cancer patients. Objective The objective is to define key indicators and identify critical variables for monitoring lung cancer care, aiming to improve early detection, reduce delays in diagnosis and treatment,…

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Identification and prioritisation of biomarkers of organophosphorus compounds-induced neurotoxicity

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Organophosphorus compounds (OPCs), a diverse group of chemicals widely utilised as pesticides and flame retardants, pose significant neurotoxic risks, even during neurodevelopment. While their primary molecular and cellular targets are well characterised, growing evidence suggest additional mechanisms, particularly in developmental neurotoxicity. Despite extensive research, predictive biomarkers of OPC-induced neurotoxicity beyond acetylcholinesterase remain underexplored. This study…

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Molecular study of vitamin D metabolism-related single nucleotide polymorphisms in cardiovascular risk: a case-control study

Artículos Científicos

Cardiovascular diseases (CVDs) constitute a major global health problem, being the leading cause of death. Several risk factors for CVDs have been identified, including tobacco use, unhealthy diet, and physical inactivity. However, the role of genetic factors in CVDs remains unclear. Recent studies suggest that vitamin D deficiency is associated with an increased risk of…

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Dietary and lifestyle determinants of vitamin D status in the UK Biobank Cohort study for predictive modeling

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Vitamin D (VD) is involved in a wide variety of physiological processes. The high prevalence of VD deficiency in the population requires stronger preventive measures. Objective Characterize the dietary and lifestyle determinants of VD levels in blood and of VD deficiency to further develop predictive models of these two outcomes. Methods 63,759 participants from…

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Correlation between tobacco control policies and the smoking behaviors of European adolescents from 2005 to 2019

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Despite legislative efforts, tobacco smoking prevalence among European adolescents remains high and heterogeneous between countries. While tobacco control policies, often assessed using Tobacco Control Scale (TCS), have been studied in adults, their influence on preventing adolescent smoking initiation remains unknown. This ecological study investigates the correlation between tobacco control policies implementation and adolescents smoking behavior…

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Examining causal relationships between educational attainment and type 2 diabetes using genetic analysis: findings from the EPIC-InterAct study through Mendelian randomisation

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Introduction Observational studies have shown that more educated people are at lower risk of developing type 2 diabetes (T2D). However, robust study designs are needed to investigate the likelihood that such a relationship is causal. This study used genetic instruments for education to estimate the effect of education on T2D using the Mendelian randomisation (MR)…

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Evaluating SinergiAPS, an intervention based on patient feedback to improve patient safety in primary care: a cluster randomized trial

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Background Patient safety, defined by the WHO as the absence of preventable harm, is a critical component of healthcare quality and poses a significant challenge globally. This study aimed to evaluate the effectiveness of SinergiAPS, a patient-centred audit and feedback intervention, in improving patient safety in primary healthcare (PHC) centres. Methods We conducted a 12-month…

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Clinical effects of probiotics on the treatment of gingivitis and periodontitis: a systematic review and meta-analysis

Artículos Científicos, Investigación

Aims This study aimed to evaluate the impact of probiotics as an adjunct to periodontal therapy on clinical outcomes in patients with gingivitis and periodontitis through a meta-analysis of available evidence. Materials and methods A detailed bibliographic search on four databases (PubMed, Scopus, Cochrane and EMBASE) was conducted with a language restriction. The collected data…