LupaDetalles

Cost-effectiveness of second- or third-line treatment with tisotumab vedotin for metastatic or recurrent cervical cancer

Artículos Científicos, Investigación

Objective To evaluate the cost-effectiveness of tisotumab vedotin (TV) versus single-agent chemotherapy in recurrent or metastatic cervical cancer (r/mCC) after failure of first-line treatment, from the perspective of the Spanish National Health System. Methods Cost-utility analysis was conducted using a partitioned survival model with three health states, over a 60-month time horizon. Efficacy data ‒overall…

Detalles

Personalized prevention of neurodegenerative diseases: scoping review and evidence gap map

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Neurodegenerative diseases represent a major public health challenge due to their high prevalence and poor prognosis. Identifying biomarkers to stratify individuals by their risk of developing these diseases may help to define new personalized prevention interventions. The objective of this study was to conduct a scoping review of biomarkers for primary and secondary personalized prevention…

LupaDetalles

The euthanasia law from the perspective of healthcare professionals in Spain

Artículos Científicos, Investigación, Mujeres EASP

Background In 2021, Spain passed Organic Law 3/2021, which regulates euthanasia and represents an extension of rights to make decisions in the context of health care. According to the Law, the state must guarantee access to Medical Assistance in Dying (MAiD) through health services. Therefore, the involvement of health professionals is crucial. The aim of…

LupaDetalles

The relationship between psychological stress and cancer incidence: a systematic review and meta-analysis

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

This systematic review of prospective studies examined whether psychological stress—conceptualised as cumulative stressful life events or perceived stress—is associated with cancer incidence. It was pre-registered in PROSPERO (IDCRD42020175681) and conducted following PRISMA guidelines. Methodological quality was assessed using the NIH Tool for Observational Studies, and the certainty of evidence was assessed using the GRADE tool.…

LupaDetalles

Cost-Utility Analysis of Left Bundle Branch Area Versus Biventricular Pacing for Cardiac Resynchronization Therapy: A Multicenter, Prospective, Quasi-Experimental Study

Artículos Científicos, Investigación, Mujeres EASP

Introduction Cardiac resynchronization therapy (CRT) is a well-established treatment for patients with heart failure (HF). Recently, left bundle branch area pacing (LBBAP) has emerged as a more physiological alternative to biventricular pacing (BVP) for CRT. This study aimed to evaluate the cost-utility of LBBAP CRT compared with BVP CRT. Methods A cost-utility, non-randomized, prospective, multicenter,…

LupaDetalles

Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Micro- and nanoplastics (MNPs) are increasingly recognized as emerging contaminants of concern for human health. Their small size, diverse composition, and reactive surface enable interactions with biological barriers and cellular systems. This comprehensive narrative review synthesizes and critically evaluates current evidence on the mechanistic effects of MNPs in humans and experimental models. Systemic mechanisms, including…

LupaDetalles

Nutrient adequacy and environmental foot-print of Mediterranean, pesco-, ovo-lacto-, and vegan menus: a modelling study

Artículos Científicos, Cáncer, Investigación

Background: Consumer food choices are changing towards a more plant-based diet (PBD) due to growing awareness of their less detrimental effects on health and the environment. However, PBDs—particularly vegan diets—may lead to nutritional deficiencies compared to non-PBDs. These differences may, in part, be influenced by the typically lower caloric content of PBDs. Objective: To compare…

LupaDetalles

What cancers are increasing in young adults: a population-based study of incidence trends in adults 20–49 years old in the South of Spain

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Recent studies have documented sharp increases in the incidence of several types of cancer in young adults, highlighting the need to monitor and understand epidemiological trends in this population. The aim of this study was to analyze cancer incidence trends among young adults (20–49 years) in the province of Granada, Spain, from 1985 to…

LupaDetalles

Synergies between food biodiversity, processing levels, and the Eat-Lancet diet for nutrient adequacy and environmental sustainability: a multi-objective optimization using the EPIC cohort

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Diets have become increasingly monotonous and high in ultra-processed foods (UPFs), contributing to poor health outcomes and environmental degradation. While sustainable diets, food biodiversity, and food processing levels have each been linked to nutritional and environmental outcomes, their combined impact has not been assessed. Objective To examine whether food biodiversity, intakes of UPFs, and…

LupaDetalles

Overcoming barriers to off-patent drug repurposing: a lifecycle-based policy solutions

Artículos Científicos, Investigación

Introduction: Drug repurposing leverages existing medicines to reduce time and costs for exploring new therapeutic indications. However, off-patent medicines do not provide enough private incentives for investment, and prescribing by active ingredient can be a major barrier. Academics and non-profit sponsors also face regulatory barriers. Methods: This study combined a structured literature review with a…