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Gestational exposure to organophosphate pesticides and maternal urine metabolomic profile in the GENEIDA birth cohort

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Early developmental exposure to organophosphate (OP) pesticides has been linked to adverse health effects, though the underlying molecular pathways remain unclear. This study examined urinary metabolomic profiles of 387 pregnant women in their first and third trimesters using UPLC-MS/MS to identify metabolic disruptions associated with OPs exposure measured via dialkyl phosphate (DAPs) metabolites, including total,…

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Thyroid hormones and epithelial ovarian cancer risk and survival: results from the European Prospective Investigation into Cancer and Nutrition study

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Thyroid-stimulating hormone (TSH) and thyroid hormones (free triiodothyronine [fT3] and free thyroxine [fT4]) may influence cancer outcomes, but evidence for ovarian cancer is limited. Methods We conducted a nested case–control study comparing 578 epithelial ovarian cancer (EOC) cases with matched controls within the European Prospective Investigation into Cancer and Nutrition (EPIC). To examine associations…

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Young Men’s Communication Needs for the Human Papillomavirus (HPV) Vaccine: A Cross-Cultural, Qualitative Analysis in Scotland, Spain, and the USA

Artículos Científicos, Cáncer, Igualdad, Investigación, Mujeres EASP

Background Globally, human papillomavirus (HPV) vaccine uptake rates have declined within a wider context of vaccine hesitancy. Gender-neutral vaccine programmes are increasing and recommended for the prevention of cervical, anogenital, and oropharyngeal cancers affecting both women and men. To address the problem of suboptimal HPV uptake rates for boys and men, we aimed to understand…

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A Framework for Considering the Role of the Public Sector in R&D of Health Technology

Artículos Científicos

The development of health technologies involves complex, costly, and risky investments, with significant contributions from both public and private sectors. Recent EU pharmaceutical directives propose transparency on public funding to aid pricing negotiations and affordability. However, questions remain regarding how public investments should be measured and their influence on pricing and reimbursement (P&R) decisions. In…

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Economic Evaluation of Treatment With Trastuzumab Deruxtecan for HER2-Low Advanced or Metastatic Breast Cancer in Previously Treated Patients

Artículos Científicos

Objectives This study evaluates the efficiency and budgetary impact of trastuzumab deruxtecan (T-DXd) compared with standard therapy in previously treated HER2-low advanced or metastatic breast cancer, from the perspective of the Spanish National Health System. Methods A partitioned survival model was developed using data from the DESTINY-BREAST04 trial. Health outcomes were measured in quality-adjusted life…

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Perceived acceptability of sexual violence against women in Spain and associated factors

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Sexual violence (SV) is considered a major public health problem affecting the lifelong health, opportunities, and wellbeing of hundreds of millions of people.1 Most recent estimates from the World Health Organization (WHO) indicate that 27 % of females aged over 15 experience physical and/or SV at the hands of their partner, whilst 6 % suffer SV from…

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Estimated exposure of flame-retardants in Spanish toddlers: a modelling approach

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Flame retardants (FRs) are chemicals used to reduce the flammability of materials and are commonly found in consumer products such as furniture and electronics. These substances can migrate from products (e.g., furniture foam and electronic devices) into indoor environments such as air and dust and may pose risk to human health by direct exposure. Some…

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Associations of internal persistent organic pollutant levels with sex hormones: An analysis by sex and menopausal status in a Spanish cohort

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

The aim of this study was to investigate associations between human exposure to persistent organic pollutants and sex hormone levels. The study population (n = 253) was a subsample of GraMo adult cohort, recruited in 2003–2004 in two hospitals from Granada, Spain. Exposure was estimated by analyzing samples of adipose tissue (3 organochlorine pesticides and…

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Body mass index and breast cancer risk among postmenopausal women with and without cardiometabolic diseases: Findings from two prospective cohort studies in Europe

Cáncer, Igualdad, Investigación, Mujeres EASP

Background Adiposity, measured by body mass index (BMI), is a known risk factor for postmenopausal breast cancer. However, whether the association of BMI with breast cancer risk differs among women with and without cardiovascular diseases (CVDs) or type 2 diabetes (T2D) is uncertain. Methods This study used individual participant data from the European Prospective Investigation…

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Desde la necesidad de información a la estrategia de búsqueda, pasando por el formato PICO

Artículos Científicos, Igualdad, Investigación, Mujeres EASP

Dado el crecimiento exponencial de la producción científica, resulta imprescindible que profesionales y la comunidad universitaria dispongan de herramientas y competencias para hacer eficiente la búsqueda de información relevante. Las necesidades de información requieren ser trabajadas y transformadas en preguntas susceptibles de ser contestadas, para lo que resulta de gran utilidad la adaptación al formato…