Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Background Hepatocellular carcinoma (HCC), the most prevalent form of liver cancer, is difficult to diagnose and has limited treatment options with a low survival rate. Aside from a few key risk factors, such as hepatitis, high alcohol consumption, smoking, obesity, and diabetes, there is incomplete etiologic understanding of the disease and little progress in identification…

Combined impact of healthy lifestyle factors on colorectal cancer: a large European cohort study

Background Excess body weight, physical activity, smoking, alcohol consumption and certain dietary factors are individually related to colorectal cancer (CRC) risk; however, little is known about their joint effects. The aim of this study was to develop a healthy lifestyle index (HLI) composed of five potentially modifiable lifestyle factors ¿ healthy weight, physical activity, non-smoking,…

Acrylamide and glycidamide hemoglobin adduct levels and endometrial cancer risk: A nested case-control study in non-smoking postmenopausal women from the EPIC cohort

Acrylamide, classified in 1994 by IARC as ‘probably carcinogenic to humans’, was discovered in 2002 in some heat-treated, carbohydrate-rich foods. Four prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The purpose of this nested case-control study, based on the European Prospective Investigation into Cancer and…