LupaDetalles

Proteomics signature of moderate-to-vigorous physical activity and risk of multimorbidity of cancer and cardiometabolic diseases

Artículos Científicos, Cáncer, Igualdad, Mujeres EASP

Background Moderate-to-vigorous physical activity (MVPA) is inversely associated with risks of cancer, cardiovascular diseases (CVD), type 2 diabetes (T2D), and their co-occurrence, defined as multimorbidity; however, the underlying biological pathways remain unclear. Methods In 33,806 UK Biobank participants with 2911 measured blood proteins, a proteomic signature of MVPA was derived with linear and LASSO regressions.…

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The complex price setting and reimbursement of non-industrial advanced therapy medicinal products

Artículos Científicos

Background Advanced Therapy Medicinal Products (ATMPs) developed under the Hospital Exemption (HE) offer innovative treatments for patients with unmet medical needs, but their pricing and reimbursement (P&R) remain fragmented and poorly understood. This paper examines the P&R landscape for HE-ATMPs developed by academic developers in Spain, based on the Spanish costing guideline and extends the…

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Factores contextuales y uso de heurísticos en atención por intensivistas a pacientes críticos durante la pandemia COVID-19: estudio cuasi-experimental con viñetas en Chile

Artículos Científicos

Introducción La decisión clínica en unidades de cuidados intensivos en pandemia por COVID-19 ha sido escasamente estudiada. Los objetivos del estudio son determinar la variabilidad de las decisiones de intensivistas en Chile, analizar la asociación de la decisión clínica con ciertos factores contextuales (hora, ola pandémica, edad del paciente, información clínica disponible) y estimar la…

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A proteomics approach to identify predictive blood biomarkers for pleural mesothelioma in prospective cohorts

Artículos Científicos, Cáncer

Background Pleural mesothelioma (PM) is a rare, asbestos-linked cancer with a long asymptomatic latency, delaying diagnosis and limiting treatment options. Identifying blood‐based biomarkers that signal disease before symptoms onset could improve surveillance of at‐risk individuals. Methods In our work, we conducted a prospective proteomic study of pre-diagnostic serum from 21 PM cases (< 5 years before…

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Policy approach to optimize multiple myeloma treatment sequencing practices

Artículos Científicos

Introduction As a consequence of major therapeutic advances that have transformed multiple myeloma (MM) into a manageable chronic condition, treatment sequencing has become highly complex. According to current practices, novel therapies are predominantly reserved for later disease stages, yet limited evidence suggests that this approach yields optimal long-term outcomes. Understanding the drivers of current practices…

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Cost-utility analysis of benzodiazepine deprescription in primary care: a cohort study

Artículos Científicos, Mujeres EASP

Background Long-term benzodiazepine (BZD) use is associated with adverse clinical outcomes and increased healthcare utilization. Although deprescription programs aim to reduce these risks, the net economic impact of BZD discontinuation—particularly in terms of healthcare resource use—remains unclear. This study aimed to evaluate the cost-utility of BZD deprescription intervention in primary care, assessing its impact on…

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Autoencoders reveal polyunsaturated fatty acids (PUFA)-Related metabolic signature linked to cancer risk

Artículos Científicos, Cáncer, Investigación

Background Metabolomics is a valuable tool for characterising biological mechanisms involved in cancer development, but produces complex datasets with intricate interdependencies. While linear dimension reduction techniques such as principal component analysis (PCA), have proven useful to summarise informative hidden patterns, biological evidence suggests metabolic relationships extend beyond linearity. Non-linear dimension reduction techniques, such as autoencoders…

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Antibody Responses to 11 Fusobacterium Proteins and Colorectal Cancer–Specific and Overall Survival in the EPIC Cohort

Artículos Científicos, Cáncer, Investigación, Mujeres EASP

Background: Although there is evidence that Fusobacterium spp. in colon tissue is associated with prognosis, less is known about the association between antibody response to antigens expressed by fusobacteria and colorectal cancer–specific mortality. Methods: Antibody responses to 11 Fusobacterium nucleatum (ATCC 25586) antigens were measured in prediagnostic blood for 471 incident colorectal cancer cases (median…