Genome-Wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale European-descent studies including up to 78,592 individuals. We identify 49 genomic regions at a false dicovery rate (FDR) < 0.05 threshold and prioritize genes…

Desigualdades de género en la autoría de las principales revistas médicas españolas durante el año 2017

Introducción El objetivo del estudio es analizar la desigualdad de género en la producción científica de las revistas médicas españolas. Material y método Estudio transversal de las principales revistas médicas españolas clasificadas por SCImago Journal & Country Ranking (n=24) y sus publicaciones (n=3.375) durante el año 2017. Se calculó la ratio mujer/hombre de autoría según…

The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries

Aim To investigate the associations between major foods and dietary fibre with subtypes of stroke in a large prospective cohort. Methods and results We analysed data on 418 329 men and women from nine European countries, with an average of 12.7 years of follow-up. Diet was assessed using validated country-specific questionnaires which asked about habitual intake over…

Psychosocial markers of pre‐hospital decision delay and psychological distress in acute coronary syndrome patients

Objectives Both pre‐hospital decision delay – the time patients wait before seeking medical attention after symptoms have started – and high psychological distress after the cardiac episode predict poor prognosis of patients with acute coronary syndromes (ACS). We aimed to identify psychosocial markers of these prognostic factors. Design A cross‐sectional study of 102 consecutive, clinically…