Early mortality in multiple myeloma: the time-dependent impact of comorbidity. A population-based study in 621 real-life patients

Multiple myeloma is a heterogeneous disease with variable survival; this variability cannot be fully explained by the current systems of risk stratification. Early mortality remains a serious obstacle to further improve the trend towards increased survival demonstrated in recent years. However, the definition of early mortality is not standardized yet. Importantly, no study has focused…

Pesticide exposure has been associated with different adverse health effects which may be modulated to some extent by paraoxonase-1 (PON1) activity and genetic polymorphisms. This study assessed seasonal variations in PON1 activity (using paraoxon –POase–, phenylacetate –AREase–, diazoxon –DZOase– and dihydrocoumarin –DHCase– as substrates), erythrocyte acetylcholinesterase (AChE) and plasma cholinesterase (using butyrylthiocholine –BuChE– and benzoylcholine…

Relationship between QT Interval Length and Arterial Stiffness in Systemic Lupus Erythematosus (SLE): A Cross-Sectional Case-Control Study

Introduction and Objectives The QT interval on the electrocardiogram has been shown to be longer in patients with systemic lupus erythematosus (SLE) compared to that of the general population. The clinical significance of this finding is unknown. The aim of this study was to assess the relationship between QT interval and subclinical atherosclerosis, measured by…